Department of Pharmaceutical Sciences, College of Pharmacy, University of Arizona, 85721, Tucson, AZ, USA.
J Am Soc Mass Spectrom. 1992 Sep;3(6):672-9. doi: 10.1016/1044-0305(92)85009-9.
The antitumor agent taxol has been examined by electron ionization, chemical ionization, and fast atom bombardment mass spectrometry. Three ion series are observed: (1) the M-series, characteristic of the intact molecule; (2) the T-series, with fragments derived from the taxane ring; and (3) the S-series representing the C-13 side chain. Neutral losses dominate each series of ions and serve to verify the presence and number of functionalities in each portion of the molecule. Fragmentation pathways and mechanisms of ion formation are proposed on the basis of product ion analysis and accurate mass measurements.
已通过电子电离、化学电离和快原子轰击质谱法对肿瘤抑制剂紫杉醇进行了研究。观察到三个离子系列：（1）M 系列，为完整分子的特征；（2）T 系列，具有来自紫杉烷环的片段；（3）S 系列代表 C-13 侧链。每个离子系列都以中性损失为主，用于验证分子各部分的存在和官能团的数量。基于产物离子分析和精确质量测量，提出了离子形成的断裂途径和机制。
