Biomedical Research Institute, Chonnam National University Hospital, Gwangju, Korea.
Department of Forensic Medicine, Chonnam National University Medical School, Gwangju, Korea,.
J Korean Med Sci. 2019 Oct 7;34(38):e246. doi: 10.3346/jkms.2019.34.e246.
C-reactive protein (CRP) is an acute-phase protein whose level increases in response to tissue injury, infection, or other inflammation. It is used in clinical and forensic settings. Point-of-care (POC) testing has recently become available, and it is considered to be useful during postmortem examinations. However, laboratory testing of postmortem blood samples is difficult due to hemolysis and postmortem clotting.
The utility of POC testing for CRP during postmortem examination was evaluated using cardiac blood from the inferior vena cava. The whole blood sample was immediately tested using the POC instrument. Subsequently, the same sample was processed to obtain the serum, which was tested using common laboratory instruments.
The postmortem POC test had a high positive predictive value and specificity, and the results strongly correlated with the laboratory test results.
POC CRP testing is valid in postmortem examination and can be used in forensic medicine (postmortem inspection and autopsy).
C 反应蛋白（CRP）是一种急性时相蛋白，其水平会在组织损伤、感染或其他炎症时升高。它在临床和法医学领域中都有应用。即时检测（POC）最近已经可用，并且在死后检查中被认为是有用的。然而，由于溶血和死后凝血，死后血液样本的实验室检测很困难。
使用下腔静脉的心脏血液评估了 POC 检测在死后检查中 CRP 的效用。立即使用 POC 仪器对全血样本进行检测。随后，对相同的样本进行处理以获得血清，并使用常规实验室仪器进行检测。
死后即时检测具有较高的阳性预测值和特异性，并且结果与实验室检测结果密切相关。
POC CRP 检测在死后检查中是有效的，可用于法医学（尸检和解剖）。
