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海曼肾炎大鼠体内预先形成的免疫复合物的清除

The clearance of pre-formed immune complexes in rats with Heymann's nephritis.

作者信息

O'Regan S

出版信息

Clin Exp Immunol. 1979 Sep;37(3):432-5.

PMID:315843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537791/
Abstract

Previous studies have indicated the presence of reticuloendothelial system (RES) depression in chronic immune complex nephritis in rabbits. To determine whether RES immune complex clearance was abnormal in Heymann's nephritis in rats, radiolabelled pre-formed immune complexes were infused into rats with membranous nephropathy. There was augmented clearance of complexes from the peripheral circulation in animals with membranous nephropathy relative to controls, indicating the absence of RES saturation.

摘要

先前的研究表明,兔慢性免疫复合物性肾炎存在网状内皮系统(RES)抑制。为了确定大鼠海曼肾炎中RES免疫复合物清除是否异常,将放射性标记的预先形成的免疫复合物注入患有膜性肾病的大鼠体内。与对照组相比,患有膜性肾病的动物外周循环中复合物的清除增加,表明不存在RES饱和。

相似文献

1
The clearance of pre-formed immune complexes in rats with Heymann's nephritis.海曼肾炎大鼠体内预先形成的免疫复合物的清除
Clin Exp Immunol. 1979 Sep;37(3):432-5.
2
Autologous immune complex nephritis in rats. Influence of modification of mononuclear phagocyte system function.大鼠自体免疫复合物性肾炎。单核吞噬细胞系统功能改变的影响。
Lab Invest. 1984 Aug;51(2):162-71.
3
Specific uptake of Heymann's nephritic kidney eluate by rat kidney: studies in vivo and in isolated perfused kidneys.大鼠肾脏对海曼肾炎肾洗脱液的特异性摄取:体内及离体灌注肾脏研究
Lab Invest. 1982 Apr;46(4):450-3.
4
Defective splenic reticuloendothelial function in idiopathic membranous nephropathy.特发性膜性肾病中脾脏网状内皮功能缺陷
Clin Exp Immunol. 1984 May;56(2):295-301.
5
Glomerular antigens in Heymann's nephritis: reactivity of eluted and circulating antibody.海曼肾炎中的肾小球抗原:洗脱抗体与循环抗体的反应性
J Immunol. 1982 Jan;128(1):323-30.
6
Passive Heymann's nephritis as a model of immune glomerulonephritis mediated by antibodies to immunoglobulins.被动型海曼肾炎作为由免疫球蛋白抗体介导的免疫性肾小球肾炎模型。
Clin Exp Immunol. 1980 Aug;41(2):189-95.
7
Absence of an anaphylactic vasopermeability mechanism for immune complex deposition in the Heymann nephritis of rats.大鼠海曼肾炎中免疫复合物沉积不存在过敏样血管通透性机制。
Clin Exp Immunol. 1980 Oct;42(1):99-106.
8
[Immune complex in glomerulonephritis-with special reference to its immunological actions].[肾小球肾炎中的免疫复合物——特别涉及其免疫作用]
Nihon Rinsho. 1974 Oct;32(10):3140-7.
9
Complement-mediated delay in immune complex clearance from the blood owing to reduced deposition outside the reticuloendothelial system.由于免疫复合物在网状内皮系统外沉积减少,补体介导的血液中免疫复合物清除延迟。
Immunology. 1983 May;49(1):53-9.
10
Circulating immune complexes in rats with autologous immune complex nephritis.患有自身免疫复合物性肾炎的大鼠体内的循环免疫复合物
Lab Invest. 1980 Jul;43(1):18-27.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions.用弗氏佐剂和大鼠肾悬液在大鼠中诱发肾病综合征
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A method of trace iodination of proteins for immunologic studies.一种用于免疫学研究的蛋白质微量碘化方法。
Int Arch Allergy Appl Immunol. 1966;29(2):185-9. doi: 10.1159/000229699.
4
Acute poststreptococcal glomerulonephritis: immune deposit disease.急性链球菌感染后肾小球肾炎:免疫沉积病。
J Clin Invest. 1966 Feb;45(2):237-48. doi: 10.1172/JCI105336.
5
Immunity deficiency in pathogenesis of glomerulonephritis.免疫缺陷在肾小球肾炎发病机制中的作用。
Lancet. 1974 Jan 12;1(7846):58-60. doi: 10.1016/s0140-6736(74)93056-6.