Zanetti M, Druet P
Clin Exp Immunol. 1980 Aug;41(2):189-95.
The autologous phase of passive Heymann's nephritis (PHN) induced in rats by a single injection of rabbit IgG anti-FxlA has been investigated. Tolerance to normal rabbit IgG prior to induction of PHN abolished or strongly diminished the glomerular deposition of the host's IgG during the early autologous phase and prevented the development of proteinuria. Neonatal thymectomy significantly decreased the anti-rabbit IgG response but did not prevent the development and the progression of glomerulopathy. Passive transfer of rat or sheep anti-rabbit IgG hyperimmune serum during the heterologous phase resulted in an earlier accumulation of the injected IgG along the glomerular capillary walls (GCW). These results demonstrate the importance of the host's humoral immune response to the injected rabbit IgG anti-FxlA antibody in the progression and in the maintenance of glomerular immune lesions.
通过单次注射兔抗FxlA IgG诱导大鼠产生的被动性海曼肾炎(PHN)的自体期已得到研究。在诱导PHN之前对正常兔IgG产生耐受性,可消除或显著减少早期自体期宿主IgG在肾小球的沉积,并预防蛋白尿的发生。新生期胸腺切除显著降低了抗兔IgG反应,但并未阻止肾小球病的发生和进展。在异种期被动转移大鼠或绵羊抗兔IgG超免疫血清,导致注入的IgG沿肾小球毛细血管壁(GCW)更早地积聚。这些结果证明了宿主对注入的兔抗FxlA抗体的体液免疫反应在肾小球免疫损伤的进展和维持中的重要性。