From the Department of Tumor Immunology and the Department of Medical Oncology.
Departments of Medical Oncology.
Clin Nucl Med. 2019 Nov;44(11):905-906. doi: 10.1097/RLU.0000000000002779.
We report a case of a 50-year-old woman treated with anti-PD-1 inhibition for metastatic melanoma. During treatment, extensive and transient histopathologically confirmed sarcoid-like reaction was detected in multiple organ systems and at different time points using F-FDG PET/CT imaging. Immune-related adverse events during anti-PD-1/PD-L1 antibody treatment are increasingly being reported. This case report emphasizes the broad spectrum of possible presentations of sarcoid-like reaction detected by F-FDG PET/CT and its evolution in time. For the clinician, awareness of these immune-related adverse events helps to accurately interpret findings on imaging.
我们报告了一例 50 岁女性接受抗 PD-1 抑制治疗转移性黑色素瘤的病例。在治疗过程中，使用 F-FDG PET/CT 成像在多个器官系统和不同时间点检测到广泛且短暂的组织病理学证实的类肉瘤样反应。越来越多的报道称，抗 PD-1/PD-L1 抗体治疗期间会发生免疫相关不良事件。本病例报告强调了 F-FDG PET/CT 检测到的类肉瘤样反应的可能表现谱及其随时间的演变。对于临床医生来说，了解这些免疫相关不良事件有助于准确解读影像学检查结果。
