Jue S G, Dawson G W, Brogden R N
Drugs. 1985 Apr;29(4):330-41. doi: 10.2165/00003495-198529040-00002.
Ciclopirox olamine is a substituted pyridone antimycotic, unrelated to the imidazole derivatives, with activity against a broad spectrum of dermatophytes, yeasts, actinomycetes, molds, other fungi, and a variety of Gram-positive and Gram-negative bacteria. The efficacy of ciclopirox olamine cream has been demonstrated in open and placebo-controlled studies in patients with superficial dermatophyte or yeast infections, and in double-blind comparative trials in patients with dermatomycoses, topical ciclopirox olamine was comparable to or better than clotrimazole in efficacy and caused a similar number of side effects. Ciclopirox olamine penetrates through fingernails and in preliminary studies has been successfully used in onychomycoses. However, further studies are needed to establish the role of ciclopirox in the treatment of onychomycoses and dermatomycoses relative to that of the more recently introduced antigungal agents.
环吡酮胺是一种取代吡啶酮类抗真菌药，与咪唑衍生物无关，对多种皮肤癣菌、酵母菌、放线菌、霉菌、其他真菌以及多种革兰氏阳性和革兰氏阴性细菌具有活性。在开放性和安慰剂对照研究中，已证实环吡酮胺乳膏对浅表皮肤癣菌或酵母菌感染患者有效；在皮肤真菌病患者的双盲对比试验中，局部使用环吡酮胺在疗效上与克霉唑相当或更佳，且副作用数量相似。环吡酮胺可穿透指甲，在初步研究中已成功用于治疗甲癣。然而，相对于最近推出的抗真菌药物，还需要进一步研究以确定环吡酮在治疗甲癣和皮肤真菌病中的作用。
