Clissold S P, Heel R C
Drugs. 1986 Jan;31(1):29-51. doi: 10.2165/00003495-198631010-00003.
Tioconazole is a substituted imidazole antimicrobial agent structurally related to other drugs in this group. It has been shown to have a broad spectrum of activity in vitro against dermatophytes and yeasts, as well as against some chlamydia, trichomonads and Gram-positive bacteria. Both open and controlled clinical trials have clearly demonstrated the efficacy and safety of topical preparations of tioconazole for treating superficial dermatophyte or yeast infections of the skin and vaginal candidiasis. In comparative studies it was at least as effective as alternative imidazole antifungal drugs, and in a few trials significantly greater efficacy has been reported for tioconazole, compared with clotrimazole, miconazole, econazole and systemic ketoconazole. Preliminary studies in other clinical areas suggest tioconazole may be useful for treating onychomycosis (in a special nail formulation), napkin-rash due to Candida albicans, impetigo, and vaginal trichomoniasis, although comparative studies are needed in each of these settings to clearly assess its relative place in therapy. Thus, tioconazole is an effective and well tolerated treatment for vaginal candidiasis and superficial fungal infections of the skin.
噻康唑是一种取代咪唑类抗菌剂，在结构上与该类中的其他药物相关。体外研究表明，它对皮肤癣菌、酵母菌以及某些衣原体、滴虫和革兰氏阳性菌具有广泛的活性。开放和对照临床试验均已明确证明，噻康唑局部制剂在治疗皮肤浅表皮肤癣菌或酵母菌感染以及阴道念珠菌病方面的有效性和安全性。在比较研究中，它至少与其他咪唑类抗真菌药物一样有效，并且在一些试验中，与克霉唑、咪康唑、益康唑和全身用酮康唑相比，噻康唑的疗效显著更高。其他临床领域的初步研究表明，噻康唑可能对治疗甲癣（采用特殊的指甲制剂）、白色念珠菌引起的尿布疹、脓疱病和阴道滴虫病有用，尽管在每种情况下都需要进行比较研究以明确评估其在治疗中的相对地位。因此，噻康唑是治疗阴道念珠菌病和皮肤浅表真菌感染的一种有效且耐受性良好的药物。
