Department of Nephrology, Rui'an people's Hospital; Room 4-3-202, Jiyun mountain road, Anyang street, Ruian, Zhejiang, 325200, P. R. China.
Department of Nephrology, Rui'an people's Hospital; Room 4-3-202, Jiyun mountain road, Anyang street, Ruian, Zhejiang, 325200, P. R. China,
Front Biosci (Landmark Ed). 2020 Jan 1;25(3):526-535. doi: 10.2741/4818.
Nephrotic syndrome (NS) is a common urinary system disease that carries a poor progrnosis due to nonresponsivess to current treatments. The purpose of this study was to investigate the therapeutic effects of Forsythiaside (FA) in a rat model of adriamycin-induced nephropathy (AN). Compared with control group, FA treatment significantly reduced proteinuria, serum creatinine and urea nitrogen levels and reduced the number of apoptotic cells in the kidneys. FA alleviated Adr induced renal injury, and increased the sactivity of superoxide dismutase (SOD), while decreasing malondialdehyde (MDA) and lactate dehydrogenase (LDH) in the serum. In addition, FA, in a dose-dependent manner, decreased the levels of NF-kappaBp65/MIP-2 in the kidenys, reduced the serum level of pro-inflammatory cytokines (IL-6, IL-1 β and TNF-alpha), and increased the survival rate of Adr treated rats. Taken together, the results show that FA alleviates renal dysfunction in adriamycin-induced nephropathy rats.
肾病综合征（NS）是一种常见的泌尿系统疾病，由于对当前治疗方法的反应不佳，预后较差。本研究旨在探讨连翘酯苷（FA）在阿霉素诱导的肾病（AN）大鼠模型中的治疗效果。与对照组相比，FA 治疗可显著减少蛋白尿、血清肌酐和尿素氮水平，并减少肾脏中的细胞凋亡数量。FA 减轻了 Adr 引起的肾脏损伤，增加了超氧化物歧化酶（SOD）的活性，同时降低了血清中丙二醛（MDA）和乳酸脱氢酶（LDH）的水平。此外，FA 还呈剂量依赖性降低了肾脏中 NF-κBp65/MIP-2 的水平，降低了促炎细胞因子（IL-6、IL-1β和 TNF-α）的血清水平，并提高了 Adr 处理大鼠的存活率。综上所述，研究结果表明，FA 可减轻阿霉素诱导的肾病大鼠的肾功能障碍。
