Alexander M, Newmark H, Miller R G
Immunol Lett. 1985;9(4):221-4. doi: 10.1016/0165-2478(85)90036-7.
Oral doses of beta-carotene (180 mg/day) given for 2 wk to normal human volunteers significantly increased the frequency of OKT4+ (helper/inducer T cells) after 7 days and of OKT3+ (all T cells) after 14 days. The frequency of OKT8+ cells was unaffected, as compared to untreated controls. Plasma levels of beta-carotene were markedly elevated throughout the study. Plasma levels of vitamin A were slightly (but significantly) elevated on days 7 and 14. No toxicity was observed. Oral beta-carotene treatment may be a clinically effective means of enhancing T4+ lymphocytes.
给正常人类志愿者口服β-胡萝卜素（180毫克/天），持续2周。7天后，OKT4 +（辅助/诱导性T细胞）的频率显著增加；14天后，OKT3 +（所有T细胞）的频率显著增加。与未治疗的对照组相比，OKT8 +细胞的频率未受影响。在整个研究过程中，血浆β-胡萝卜素水平显著升高。在第7天和第14天，血浆维生素A水平略有（但显著）升高。未观察到毒性。口服β-胡萝卜素治疗可能是增强T4 +淋巴细胞的一种临床有效方法。
