Division of Reproduction, Department of Obstetrics, Gynecology, and Gynecologic Oncology, Poznan University of Medical Sciences, Poznan, Poland.
Division of Reproduction, Department of Obstetrics, Gynecology, and Gynecologic Oncology, Poznan University of Medical Sciences, Poznan, Poland.
Pregnancy Hypertens. 2019 Oct;18:108-111. doi: 10.1016/j.preghy.2019.08.165. Epub 2019 Oct 3.
The study aimed to assess serum levels of syndecan-1 (SDC-1) and hyaluronan (HA) in patients with early- and late-onset preeclampsia (PE).
Blood samples were collected in the third trimester of pregnancy from 20 women with early-onset PE, 20 with late-onset PE, and 20 with normal pregnancy for the assessment of serum levels of SDC-1 and HA as markers of endothelial injury. PE was categorized as early-onset when diagnosed at <34 weeks of gestation and as late-onset when diagnosed at ≥34 weeks of gestation.
The degree of endothelial injury in different forms of preeclampsia expressed by serum concentrations of SDC-1 and HA.
Concentration of HA was significantly higher and the level of SDC-1 was significantly lower in patients with PE than in the control group. However, the concentrations of both HA and SDC-1 did not differ significantly between the two groups of PE.
Degree of endothelium injury is comparable in patients with early- and late-onset PE.
本研究旨在评估早发型和晚发型子痫前期（PE）患者血清中 syndecan-1（SDC-1）和透明质酸（HA）的水平。
在妊娠晚期采集 20 例早发型 PE、20 例晚发型 PE 和 20 例正常妊娠孕妇的血样，以评估 SDC-1 和 HA 作为内皮损伤标志物的血清水平。PE 被定义为在 <34 孕周时诊断为早发型，在≥34 孕周时诊断为晚发型。
不同形式的子痫前期患者血清 SDC-1 和 HA 浓度表达的内皮损伤程度。
PE 患者的 HA 浓度显著高于对照组，SDC-1 水平显著低于对照组。然而，两组 PE 患者的 HA 和 SDC-1 浓度均无显著差异。
早发型和晚发型 PE 患者的内皮损伤程度相当。
