George Kitty, Poudel Prakar, Chalasani Roopa, Goonathilake Mastiyage R, Waqar Sara, George Sheeba, Jean-Baptiste Wilford, Yusuf Ali Amina, Inyang Bithaiah, Koshy Feeba Sam, Mohammed Lubna
Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Pediatrics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus. 2022 Jun 9;14(6):e25794. doi: 10.7759/cureus.25794. eCollection 2022 Jun.
Exploration of novel biomarkers has been gaining popularity in preeclampsia, which is currently being diagnosed based on clinical criteria alone. Soluble syndecan-1, released from one of the proteoglycans associated with the syncytiotrophoblastic layer of the placenta, is affected in patients with abnormal placentation. This article is the first systematic literature review that evaluates the relationship between the antepartum serum levels of the syndecan-1 and preeclampsia. Eight studies were selected after screening and quality appraisal, and data were analyzed. The serum concentration of syndecan-1 was found to correlate positively with the gestational age in all pregnancies and negatively with the systolic blood pressure in patients with preeclampsia. Extremely low levels of soluble syndecan-1 may be helpful as a predictor for the development of preeclampsia during gestation.
新型生物标志物的探索在子痫前期领域越来越受到关注，目前子痫前期仅根据临床标准进行诊断。可溶性syndecan-1是从与胎盘合体滋养层相关的一种蛋白聚糖释放出来的，在胎盘形成异常的患者中会受到影响。本文是第一项系统的文献综述，评估了产前血清syndecan-1水平与子痫前期之间的关系。经过筛选和质量评估后选择了八项研究，并对数据进行了分析。发现syndecan-1的血清浓度在所有妊娠中与孕周呈正相关，而在子痫前期患者中与收缩压呈负相关。极低水平的可溶性syndecan-1可能有助于预测妊娠期子痫前期的发生。
