Department of Neurology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mult Scler Relat Disord. 2019 Nov;36:101415. doi: 10.1016/j.msard.2019.101415. Epub 2019 Sep 26.
A large number of multiple sclerosis [MS] patients suffer from cognitive dysfunction affecting their routine life in family and society. Investigating modifiable factors for cognition decline and controlling them, could improve the quality of life in MS patients. Therefore, the present study was aimed to evaluate the association between lipid profile components and cognition in MS patients.
A cross-sectional study was conducted on 50 Relapsing-Remitting MS (RRMS) patients referred to Sina hospital, Tehran, Iran. The definite diagnosis of MS was done based on the revised McDonald criteria. Data on demographic and clinical data of patients were obtained. 5 cc blood samples were taken from all subjects after 10-hour night fasting, and lipid profile components including LDL, HDL, triglyceride, and total cholesterol were evaluated. The Persian version of the Minimal Assessment of Cognitive Functions in MS [MACFIMS] battery was administered to assess the cognitive function. Spearman and Pearson correlation tests were applied to investigate the correlation between lipid profile components and MACFIMS subtests or clinical features of MS patients.
The mean age of subjects was equal to 32.26 years old, and 85% of them were women. There was no significant correlation between MACFIMS subtests results with disease duration, patient's disability according to Expanded Disability Status Scale (EDSS), annual attack rate, and disease-modifying drug onset year (P value >0.05). A significant inverse correlation was found between greater serum total cholesterol and lower scores of Symbol Digit Modalities subtest [SDMT] (P value 0.02; r: -0.31), the Delis-Kaplan Executive Function System [DKEFS] sorting (P value 0.01; r: -0.34) and DKEFS-descriptive (P value 0.04; r: -0.28) subtests. This significant inverse correlation was also found in terms of the correlation between higher serum LDL and impairment in the case of DKEFS-sorting score (P value 0.05; r: -0.27), and DKEFS-descriptive score (P value 0.05; r: -0.27). No significant correlation was found in case of serum HDL or triglyceride and MACFIMS subtests (P value >0.05).
Our findings proposed a possible correlation between the increased serum LDL cholesterol, serum total cholesterol and cognitive dysfunction among MS patients.
大量多发性硬化症（MS）患者存在认知功能障碍，影响其在家庭和社会中的日常生活。研究认知能力下降的可改变因素并加以控制，可以提高 MS 患者的生活质量。因此，本研究旨在评估 MS 患者血脂成分与认知功能之间的关系。
本横断面研究纳入了 50 名来自伊朗德黑兰 Sina 医院的复发缓解型多发性硬化症（RRMS）患者。MS 的明确诊断基于修订后的 McDonald 标准。收集患者的人口统计学和临床数据。所有受试者均在禁食 10 小时后采集 5cc 血样，评估血脂成分，包括 LDL、HDL、甘油三酯和总胆固醇。采用波斯语版多发性硬化症认知功能简易评估量表（MACFIMS）评估认知功能。采用 Spearman 和 Pearson 相关检验分析血脂成分与 MACFIMS 子测试或 MS 患者临床特征之间的相关性。
受试者的平均年龄为 32.26 岁，85%为女性。MACFIMS 子测试结果与疾病持续时间、扩展残疾状况量表（EDSS）评分、年复发率和疾病修正治疗开始时间无显著相关性（P 值均>0.05）。血清总胆固醇水平与符号数字模态测试（SDMT）子测试评分（P 值 0.02；r：-0.31）、Delis-Kaplan 执行功能系统（DKEFS）分类测试（P 值 0.01；r：-0.34）和 DKEFS 描述性测试（P 值 0.04；r：-0.28）呈显著负相关。血清 LDL 水平与 DKEFS 分类测试评分（P 值 0.05；r：-0.27）和 DKEFS 描述性测试评分（P 值 0.05；r：-0.27）呈显著负相关。而血清 HDL 或甘油三酯与 MACFIMS 子测试无显著相关性（P 值>0.05）。
我们的研究结果表明，MS 患者血清 LDL 胆固醇、总胆固醇升高可能与认知功能障碍有关。
