Multiple Sclerosis Research Center, Neuroscience institute, Tehran University of Medical sciences, Tehran, Iran.
Multiple Sclerosis Research Center, Neuroscience institute, Tehran University of Medical sciences, Tehran, Iran; Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mult Scler Relat Disord. 2020 Jul;42:102132. doi: 10.1016/j.msard.2020.102132. Epub 2020 Apr 28.
Given some evidence on the effects of vitamin B6 on cognitive function and the high prevalence of cognitive impairment in patients with Neuromyelitis Optica Spectrum Disorder (NMOSD), we conducted the present study to evaluate the correlation between dietary vitamin B6 intake and cognitive function among NMOSD patients.
A cross-sectional study was designed on 24 definite NMOSD patients in Sina hospital, Tehran, Iran. A validated 168-item food frequency questionnaire was used to obtain the participants' routine dietary habits. For the cognitive function assessment, Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery was administered. Vitamin B6 intake per day was calculated, and the correlation between vitamin B6 and the results of MACFIMS subtests was examined.
The results revealed a positive correlation between dietary vitamin B6 intake and cognitive function in all subtests of MACFIMS. This direct correlation was significant in case of verbal and learning memory according to CVLT-II subtest (p-value:0.02; r:0.45) as well as speed of information processing and working memory according to SDMT subtest (p-value:0.04; r:0.43). The results from linear regression analysis adjusted for carbohydrate intake and disease duration indicated a significant ascending trend for the score of CVLT-II, SDMT, CVLT-II-delayed recall, and Brief Visuospatial Memory Test-Revised (BVMT-R) subtests through the quartiles of vitamin B6 intakes.
Our finding indicated a positive correlation between higher dietary intake of vitamin B6 and cognitive function of NMOSD patients. Based on high prevalence of cognitive malfunction in NMOSD patients, these results are promising.
鉴于维生素 B6 对认知功能的影响的一些证据，以及视神经脊髓炎谱系疾病（NMOSD）患者认知障碍的高患病率，我们进行了本研究，以评估 NMOSD 患者饮食中维生素 B6 摄入量与认知功能之间的相关性。
本研究采用横断面设计，在伊朗德黑兰的 Sina 医院纳入了 24 例确诊的 NMOSD 患者。使用经过验证的 168 项食物频率问卷来获取参与者的常规饮食习惯。为了评估认知功能，使用了多发性硬化症最小认知功能评估量表（MACFIMS）成套测验。计算了每天的维生素 B6 摄入量，并检查了维生素 B6 与 MACFIMS 子测验结果之间的相关性。
结果显示，饮食中维生素 B6 摄入量与 MACFIMS 的所有子测验中的认知功能呈正相关。根据 CVLT-II 子测验中的言语和学习记忆（p 值：0.02；r：0.45）以及 SDMT 子测验中的信息处理速度和工作记忆（p 值：0.04；r：0.43），这种直接相关性具有统计学意义。经碳水化合物摄入量和疾病持续时间调整的线性回归分析表明，通过维生素 B6 摄入量的四分位数，CVLT-II、SDMT、CVLT-II 延迟回忆和简易视觉空间记忆测验修订版（BVMT-R）子测验的得分呈显著上升趋势。
我们的研究结果表明，NMOSD 患者饮食中维生素 B6 摄入量较高与认知功能呈正相关。鉴于 NMOSD 患者认知功能障碍的高患病率，这些结果很有前景。
