鼻腔息肉上皮异型性与镍和铜暴露。
Nasal polyp epithelial atypia and exposure to nickel and copper.
机构信息
Department of Otorhinolaryngology, Military Medical Academy Faculty of Medicine, Crnotravska, Belgrade, Serbia.
Institute for Pathology, Military Medical Academy Faculty of Medicine, Crnotravska, Belgrade, Serbia.
出版信息
Occup Med (Lond). 2020 Mar 12;70(1):72-74. doi: 10.1093/occmed/kqz123.
BACKGROUND
Possible factors for cell atypia in nasal mucosa include noxious chemicals: ammonia, formaldehyde and heavy metals.
AIMS
Case presentation of a nasal polyp with epithelial dysplasia in a worker exposed to nickel and copper salt dust.
CASE REPORT
A 27-year-old man complained of impaired nasal breathing and mild right-sided epistaxis. He was exposed to copper and nickel salt dust for 6 years. Clinical examination showed a polypoid lesion arising from the right middle turbinate. Histopathological examination of the excised lesion showed high-grade epithelial dysplasia. Duration of exposure and concentration of heavy metals in serum suggest the biological plausibility of exposure to these factors and development of epithelial dysplasia in the nasal mucosa.
CONCLUSIONS
Epithelial dysplasia may occasionally be noted in inflammatory nasal polyps, especially in workers exposed to heavy metals.
背景
导致鼻腔黏膜细胞非典型性的可能因素包括有害化学物质：氨、甲醛和重金属。
目的
报道一例接触镍和铜盐粉尘的工人发生鼻息肉伴上皮异型增生的病例。
病例报告
一名 27 岁男性因鼻塞和轻微右侧鼻出血就诊。他接触铜和镍盐粉尘已有 6 年。临床检查显示右侧中鼻甲有息肉样病变。切除病变的组织病理学检查显示高级别上皮异型增生。接触时间和血清中重金属浓度提示这些因素的暴露和鼻黏膜上皮异型增生的发生具有生物学可能性。
结论
上皮异型增生偶尔可在炎症性鼻息肉中见到，尤其是在接触重金属的工人中。
Zotero 插件