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[男性不育中的抗精子自身抗体。MAR试验检测表面免疫球蛋白G的价值]

[Antispermatozoa autoantibodies in male sterility. Value of the detection of surface immunoglobulins G by the MAR test].

作者信息

Carre-Pigeon F, Teyssier J R, Bajolle F, Melin M C, Ferre D

出版信息

Presse Med. 1985 May 4;14(18):1005-8.

PMID:3158944
Abstract

The mixed antiglobulin reaction (MAR) test for immunoglobulins G was performed on 574 spermograms, resulting in the detection of surface auto-antibodies directed against spermatozoa in 4.18% of the cases. Concomitant investigations of spermograms for spontaneous agglutination and cross-penetration in a control cervical mucus, together with assays of antispermatozoa antibodies in serum and seminal fluid, have led to the diagnosis of asthenospermia in 87.5% of the cases. Spontaneous sperm agglutination was present in all cases; the cross-penetration test was negative or doubtful in 92.3%. Auto-antibodies against spermatozoa were found in 76.2% of serum and/or seminal fluid samples.

摘要

对574份精液分析进行了针对免疫球蛋白G的混合抗球蛋白反应(MAR)检测,结果在4.18%的病例中检测到针对精子的表面自身抗体。同时对精液分析进行了针对自发凝集和在对照宫颈黏液中的交叉穿透情况的研究,以及血清和精液中抗精子抗体的检测,结果在87.5%的病例中诊断出弱精子症。所有病例均存在自发精子凝集;交叉穿透试验在92.3%的病例中为阴性或可疑。在76.2%的血清和/或精液样本中发现了抗精子自身抗体。

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