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燕麦β-葡聚糖膳食补充剂对结肠炎的有益作用取决于其分子量。

Beneficial Effects of Oat Beta-Glucan Dietary Supplementation in Colitis Depend on its Molecular Weight.

机构信息

.Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warsaw, Poland.

.Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159, 02-776 Warsaw, Poland.

出版信息

Molecules. 2019 Oct 5;24(19):3591. doi: 10.3390/molecules24193591.

DOI:10.3390/molecules24193591
PMID:31590413
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6804032/
Abstract

BACKGROUND

Inflammatory bowel diseases are an important health problem. Therefore, the aim of the present study was to compare the impact of isolated oat beta-glucan fractions of low and high molecular weight, taken as dietary supplementation, on inflammatory markers in the colitis model.

METHODS

Two groups of Sprague-Dawley rats-control and with experimentally induced colitis-were subsequently divided into three subgroups and fed over 21 days feed supplemented with 1% of low (βGl) or high (βGh) molecular weight oat beta-glucan fraction or feed without supplementation. The level of colon inflammatory markers, cytokines, and their receptors' genes expressions and immune cells numbers were measured by ELISA, RT-PCR, and by flow cytometry methods, respectively.

RESULTS

The results showed moderate inflammation affecting the colon mucosa and submucosa, with significant changes in the number of lymphocytes in the colon tissue, elevated cytokines and eicosanoid levels, as well as disruption of the main cytokine and chemokine cell signaling pathways in colitis rats. Beta-glucans supplementation caused a reverse in the percentage of lymphocytes with stronger effects of βGh and reduction of the levels of the inflammatory markers, and improvement of cytokine and chemokine signaling pathways with stronger effects of βGl supplementation.

CONCLUSIONS

The results indicate the therapeutic effect of dietary oat beta-glucan supplementation in the colitis in evident relation to the molecular weight of polymer.

摘要

背景

炎症性肠病是一个重要的健康问题。因此，本研究的目的是比较作为膳食补充剂的低和高分子量的分离燕麦β-葡聚糖对结肠炎模型中炎症标志物的影响。

方法

两组 Sprague-Dawley 大鼠-对照组和实验性诱导结肠炎组-随后分为三组，分别用补充 1%低（βGl）或高分子量（βGh）燕麦β-葡聚糖或无补充的饲料喂养 21 天。通过 ELISA、RT-PCR 和流式细胞术方法分别测量结肠炎症标志物、细胞因子及其受体基因表达和免疫细胞数量。

结果

结果表明，炎症影响结肠黏膜和黏膜下层，结肠炎大鼠结肠组织中淋巴细胞数量显著增加，细胞因子和类花生酸水平升高，以及主要细胞因子和趋化因子细胞信号通路受损。β-葡聚糖补充导致淋巴细胞的百分比发生逆转，βGh 的作用更强，炎症标志物的水平降低，细胞因子和趋化因子信号通路得到改善，βGl 补充的作用更强。

结论

结果表明，膳食燕麦β-葡聚糖补充在结肠炎中的治疗效果与聚合物的分子量有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/c9b1efefb51e/molecules-24-03591-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/e174780cb673/molecules-24-03591-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/26665fba0daf/molecules-24-03591-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/c32f2ec45b5d/molecules-24-03591-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/c218c3849a69/molecules-24-03591-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/28a4dde20aa3/molecules-24-03591-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/c2cccbd85e98/molecules-24-03591-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/fa291c1bcb36/molecules-24-03591-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/3ad71db776f8/molecules-24-03591-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/c9b1efefb51e/molecules-24-03591-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/e174780cb673/molecules-24-03591-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/26665fba0daf/molecules-24-03591-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/c32f2ec45b5d/molecules-24-03591-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/c218c3849a69/molecules-24-03591-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/28a4dde20aa3/molecules-24-03591-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/c2cccbd85e98/molecules-24-03591-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/fa291c1bcb36/molecules-24-03591-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/3ad71db776f8/molecules-24-03591-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6804032/c9b1efefb51e/molecules-24-03591-g009.jpg

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