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增殖性肾病和增殖性黑化综合征与前阿尔卑斯伊萨尔河褐鳟（）的死亡有关。

Proliferative Kidney Disease and Proliferative Darkening Syndrome are Linked with Brown Trout () Mortalities in the Pre-Alpine Isar River.

作者信息

Arndt Daniela, Fux Robert, Blutke Andreas, Schwaiger Julia, El-Matbouli Mansour, Sutter Gerd, Langenmayer Martin C

机构信息

Institute for Infectious Diseases and Zoonoses, LMU Munich, 80539 Munich, Germany.

German Center for Infection Research (DZIF), Partner Site Munich, 80539 Munich, Germany.

出版信息

Pathogens. 2019 Oct 6;8(4):177. doi: 10.3390/pathogens8040177.

DOI:10.3390/pathogens8040177
PMID:31590460
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6963635/
Abstract

For many years, brown trout () mortalities within the pre-alpine Isar River in Germany were reported by the Bavarian Fisheries Association (Landesfischereiverband Bayern e.V.) and local recreational anglers during August and September. Moribund fish seemed to be affected by proliferative darkening syndrome (PDS). In addition, proliferative kidney disease (PKD) caused by was discussed. To investigate this phenomenon, the present field study monitored brown trout mortalities by daily river inspection in 2017 and 2018. Moribund brown trout (n = 31) were collected and examined using histology, immunohistochemistry, qPCR, and quantitative stereology. Our investigations identified 29 (93.5%) brown trout affected by PKD. Four brown trout (12.9%) displayed combined hepatic and splenic lesions fitting the pathology of PDS. The piscine orthoreovirus 3, suspected as causative agent of PDS, was not detectable in any of the samples. Quantitative stereological analysis of the kidneys revealed a significant increase of the renal tissue volumes with interstitial inflammation and hematopoietic hyperplasia in PKD-affected fish as compared to healthy brown trout. The identified T strain was classified as part of the North American clade by phylogenetical analysis. This study highlights PKD and PDS as contributing factors to recurrent autumnal brown trout mortalities.

摘要

多年来，德国巴伐利亚渔业协会（Landesfischereiverband Bayern e.V.）和当地休闲垂钓者报告称，在阿尔卑斯山前伊萨尔河中的褐鳟（）在8月和9月出现死亡情况。濒死的鱼似乎受到增殖性黑化综合征（PDS）的影响。此外，还讨论了由引起的增殖性肾病（PKD）。为调查这一现象，本实地研究在2017年和2018年通过每日河流巡查监测褐鳟死亡情况。收集濒死褐鳟（n = 31）并使用组织学、免疫组织化学、qPCR和定量体视学进行检查。我们的调查发现29条（93.5%）褐鳟受到PKD影响。4条褐鳟（12.9%）表现出符合PDS病理特征的肝脏和脾脏联合病变。在任何样本中均未检测到疑似为PDS病原体的鱼类正呼肠孤病毒3。对肾脏的定量体视学分析显示，与健康褐鳟相比，受PKD影响的鱼的肾组织体积显著增加，伴有间质性炎症和造血组织增生。通过系统发育分析，鉴定出的T株被归类为北美进化枝的一部分。本研究强调PKD和PDS是秋季褐鳟反复死亡的促成因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2289/6963635/0c1bc4a62e19/pathogens-08-00177-g009.jpg
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