心叶山麻杆、无根藤和檀香紫檀组合用于腹泻性细菌感染
Combinations of Alchornea cordifolia, Cassytha filiformis and Pterocarpus santalinoides in diarrhoegenic bacterial infections.
作者信息
Oli Angus Nnamdi, Obaji Monday, Enweani Ifeoma Bessie
机构信息
Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
Department of Medical Laboratory Science, Faculty of Health Science and Technology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Nigeria.
出版信息
BMC Res Notes. 2019 Oct 7;12(1):649. doi: 10.1186/s13104-019-4687-0.
OBJECTIVES
This study examines the rationale, if any, behind combining the extracts from the fruits of Alchornea cordifolia and Pterocarpus santalinoides and aerial parts of Cassytha filiformis in the traditional treatment of diarrhoegenic bacterial infections.
RESULTS
Four diarrhoegenic bacterial isolates: Salmonella typhi, Shigellae dysenteriae, Escherichia coli and Staphylococcus aureus were used and their antibiotic susceptibility screening showed that they were multi-antibiotic resistant. The extracts exhibited activity against all the test isolates with minimum inhibitory concentration values ranging from 3.125 to 12.5 mg/mL. From the checkerboard assay, the fractional inhibitory concentration indices showed that C. filiformis has antagonistic and indifference activities in combination with either P. santalinoides or A. cordifolia. This showed that the combination of extracts from the fruits of A. cordifolia and P. santalinoides and aerial parts of C. filiformis is counterproductive and invalidates any claim for positive results in the management of diarrhoegenic bacterial infections.
目的
本研究探讨在传统治疗腹泻性细菌感染中，将心叶山麻杆果实、檀香紫檀果实及无根藤地上部分的提取物混合使用背后的理论依据（若有）。
结果
使用了四种腹泻性细菌分离株：伤寒沙门氏菌、痢疾志贺氏菌、大肠杆菌和金黄色葡萄球菌，其抗生素敏感性筛选表明它们具有多重耐药性。提取物对所有测试分离株均表现出活性，最低抑菌浓度值范围为3.125至12.5毫克/毫升。从棋盘格试验来看，部分抑菌浓度指数表明无根藤与檀香紫檀或心叶山麻杆联合使用时具有拮抗和无相互作用活性。这表明心叶山麻杆果实、檀香紫檀果实及无根藤地上部分的提取物组合会适得其反，并且在腹泻性细菌感染管理中任何关于取得阳性结果的说法都站不住脚。
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