Mohammadi Zahed, Jafarzadeh Hamid, Shalavi Sousan, Yaripour Shapour, Sharifi Farid, Kinoshita Jun-Ichiro
Iranian Center for Endodontic Research, Research Institute of Dental Sciences, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran and Iranian National Elite Foundation, Tehran, Iran.
Dental Research Center, Dental School, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran Endod J. 2018 Winter;13(1):1-6. doi: 10.22037/iej.v13i1.17941.
As the root canal system shows different and complicated anatomies, mechanical instrumentation alone has not the ability to provide a bacteria-free environment in root canals. On the other aspect, necrotic tissue remaining can decrease the effects of root canal irrigants and medicaments and also interfere with the adaptation of root canal fillings to dentin. As a result, certain disinfection and irrigation procedures are required to remove the remaining tissues from the root canal area thoroughly and also be able to eliminate the microorganisms. Triple antibiotic paste (TAP) containing metronidazole, ciprofloxacin and minocycline has been proposed as a root canal medicament due to its antimicrobial effects in endodontic regenerative procedures. The purposes of this review were to determine the properties of TAP drugs and to evaluate the efficiency of TAP on the root canal disinfection, in primary and permanent teeth, along with its affection in regeneration/revascularization procedures. The biocompatibility and disadvantages of this medicament were also discussed.
由于根管系统呈现出不同且复杂的解剖结构，仅靠机械预备无法在根管内营造无菌环境。另一方面，残留的坏死组织会降低根管冲洗剂和药物的效果，还会干扰根管充填材料与牙本质的适配。因此，需要特定的消毒和冲洗程序来彻底清除根管区域的残留组织，并消除微生物。含甲硝唑、环丙沙星和米诺环素的三联抗生素糊剂（TAP）因其在牙髓再生程序中的抗菌作用，已被提议作为一种根管药物。本综述的目的是确定TAP药物的特性，评估TAP在乳牙和恒牙根管消毒中的效果，以及其在再生/血管化程序中的作用。还讨论了这种药物的生物相容性和缺点。
