Daniel M D, Letvin N L, King N W, Kannagi M, Sehgal P K, Hunt R D, Kanki P J, Essex M, Desrosiers R C
Science. 1985 Jun 7;228(4704):1201-4. doi: 10.1126/science.3159089.
The isolation of a T-cell tropic retrovirus from three immunodeficient macaques and one macaque with lymphoma is described. The morphology, growth characteristics, and antigenic properties of this virus indicate that it is related to the causative agent of acquired immune deficiency syndrome in humans (HTLV-III or LAV). This virus is referred to as simian T-lymphotropic virus type III (STLV-III) of macaques. The existence of a cytopathic, T-cell tropic virus resembling HTLV-III in monkeys may facilitate study of disease induction and vaccine development in an animal model.
本文描述了从三只免疫缺陷猕猴和一只患有淋巴瘤的猕猴中分离出一种嗜T细胞逆转录病毒。该病毒的形态、生长特性和抗原特性表明，它与人类获得性免疫缺陷综合征的病原体（HTLV-III或LAV）有关。这种病毒被称为猕猴猿猴嗜T淋巴细胞病毒III型（STLV-III）。在猴子中存在一种类似于HTLV-III的细胞病变性嗜T细胞病毒，这可能有助于在动物模型中研究疾病诱导和疫苗开发。
