Franchini G, Gurgo C, Guo H G, Gallo R C, Collalti E, Fargnoli K A, Hall L F, Wong-Staal F, Reitz M S
Nature. 1987;328(6130):539-43. doi: 10.1038/328539a0.
The characterization of HIV-1 (HTLV-III/LAV), the human retrovirus associated with AIDS (acquired immune deficiency syndrome) has led to the identification of a group of related human and simian retroviruses which also infect CD4-bearing T lymphocytes. Simian T-lymphotropic virus type III (simian immodeficiency virus) from macaques (STLV-IIIMAC) induces symptoms similar to those of AIDS in infected macaques, but isolates from African green monkeys (STLV-IIIAGM) and mangabeys (STLV-IIMM) appear to be non-pathogenic in these animals. A human virus immunologically related to STLV-IIIAGM (HTLV-IV), reported to have been isolated from healthy humans, has been shown to be almost identical to STLV-IIIAGM, which has called into question the independent origin of these viruses. Here we report the complete DNA sequence of STLV-IIIAGM and analyse its relationship with the genomes of the HTLV-IIIB strain of HIV-1, HIV-2ROD (previously called LAV-2) and several ungulate lentiretroviruses. STLV-IIIAGM and HIV-2 are closely related, and more distantly related to HIV-1.
与获得性免疫缺陷综合征（AIDS）相关的人类逆转录病毒HIV-1（HTLV-III/LAV）的特征鉴定，促使人们识别出一组相关的人类和猿猴逆转录病毒，它们也感染表达CD4的T淋巴细胞。来自猕猴的猿猴嗜T淋巴细胞病毒III型（猿猴免疫缺陷病毒，STLV-IIIMAC）在受感染的猕猴中引发类似于AIDS的症状，但来自非洲绿猴（STLV-IIIAGM）和白眉猴（STLV-IIMM）的分离株在这些动物中似乎无致病性。一种在免疫学上与STLV-IIIAGM相关的人类病毒（HTLV-IV），据报道已从健康人身上分离出来，结果显示它与STLV-IIIAGM几乎完全相同，这对这些病毒的独立起源提出了质疑
