Godden U, Herbert J, Stewart R D, Roser B
Transplantation. 1985 Jun;39(6):624-8. doi: 10.1097/00007890-198506000-00010.
During treatment of heart-grafted rats with cyclosporine, an unusual large lymphocyte appears in the blood. These cells constitute up to 40% of the peripheral blood leukocyte population and carry both the T helper/DTH and T cytotoxic/suppressor differentiation antigens. They require both the allograft and CsA for their generation and are not recently thymus-derived. They gradually disappear after stopping CsA treatment, although the treated rats remain tolerant of the graft.
在用环孢素治疗心脏移植大鼠的过程中，血液中出现了一种异常的大淋巴细胞。这些细胞占外周血白细胞总数的40%，同时携带T辅助/迟发型超敏反应和T细胞毒性/抑制性分化抗原。它们的产生既需要同种异体移植物，也需要环孢素，且并非近期来源于胸腺。尽管接受治疗的大鼠对移植物仍保持耐受，但停止环孢素治疗后，这些细胞会逐渐消失。
