Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
College of Animal Science and Technology, Zhejiang A&F University, Hangzhou, Zhejiang, China.
Anim Biotechnol. 2021 Apr;32(2):169-177. doi: 10.1080/10495398.2019.1671858. Epub 2019 Oct 8.
() is characterized by its critical functions in osteoblastic and ovulatory processes. The goal of this study was to explore the insertion/deletion (indel) variants of this gene and to evaluate their association with productive traits. Herein, a 12 bp and 6 bp insertion within the gene was uncovered in Shaanbei white cashmere goats (SBWC; = 1200). Chi-square analysis revealed that the 12 bp insertion was related to litter size ( < 0.01). Further association analysis also found this insertion was significantly associated with litter size ( = 1.1E-5). Interestingly, this insertion was also significantly associated with chest circumference ( = 0.018). Additionally, the 6 bp insertion was associated with body length ( = 0.003), chest width ( = 0.011), and chest circumference ( = 0.005). Furthermore, diplotype associations also uncovered that the combined genotypes of these two indels also significantly affected litter size and growth traits ( < 0.05). These findings suggested that these two insertions within the gene were significantly associated with reproduction and growth traits, which would make them beneficial functional DNA markers that can be used in goat breeding.
（）的功能对成骨细胞和排卵过程至关重要。本研究的目的是探索该基因的插入/缺失（indel）变体，并评估它们与生产性状的关系。在此，在陕北白绒山羊（SBWC；= 1200）中发现了基因内的 12bp 和 6bp 插入。卡方分析显示，12bp 插入与产羔数有关（<0.01）。进一步的关联分析还发现，这种插入与产羔数显著相关（= 1.1E-5）。有趣的是，这种插入也与胸围显著相关（= 0.018）。此外，6bp 插入与体长（= 0.003）、胸宽（= 0.011）和胸围（= 0.005）有关。此外，二倍型关联还发现，这两个插入的组合基因型也显著影响产羔数和生长性状（<0.05）。这些发现表明，基因内的这两个插入与繁殖和生长性状显著相关，这使它们成为可用于山羊育种的有益功能 DNA 标记。
