Detection of insertions/deletions (InDels) within the goat gene and their association with litter size and growth traits.

() is characterized by its critical functions in osteoblastic and ovulatory processes. The goal of this study was to explore the insertion/deletion (indel) variants of this gene and to evaluate their association with productive traits. Herein, a 12 bp and 6 bp insertion within the gene was uncovered in Shaanbei white cashmere goats (SBWC;  = 1200). Chi-square analysis revealed that the 12 bp insertion was related to litter size ( < 0.01). Further association analysis also found this insertion was significantly associated with litter size ( = 1.1E-5). Interestingly, this insertion was also significantly associated with chest circumference ( = 0.018). Additionally, the 6 bp insertion was associated with body length ( = 0.003), chest width ( = 0.011), and chest circumference ( = 0.005). Furthermore, diplotype associations also uncovered that the combined genotypes of these two indels also significantly affected litter size and growth traits ( < 0.05). These findings suggested that these two insertions within the gene were significantly associated with reproduction and growth traits, which would make them beneficial functional DNA markers that can be used in goat breeding.