Pandit Ashiq Hussain, Mazumdar Nasreen, Imtiyaz Khalid, Rizvi M Moshahid Alam, Ahmad Sharif
Materials Research Laboratory, Department of Chemistry, Material (Polymer) Research Laboratory, Department of Chemistry, and Genome Biology Laboratory, Department of Biosciences, Jamia Millia Islamia, New Delhi 110025, India.
ACS Omega. 2019 Sep 18;4(14):16026-16036. doi: 10.1021/acsomega.9b02137. eCollection 2019 Oct 1.
The chemically oxidized gum arabic was prepared and used as a naturally derived nontoxic and pH-responsive cross-linker to develop smart polyvinyl alcohol (PVA)-based hydrogels for the first time. The formulated hydrogels exhibited high mechanical properties, good porosity, and pH sensitivity, which facilitated their application as promising biomaterials for sustained delivery of folic acid. Further, the synthesized cross-linked PVA hydrogels displayed no cytotoxicity toward the human embryonic kidney cell line and exhibited higher blood compatibility. The hydrolytic degradation study confirmed their biodegradable nature. While the sustained delivery along with photoprotective properties of these hydrogels confirmed their multifunctional characteristics, these results suggest that these hydrogels may act as an efficient photoprotective material and find their application in the field of drug delivery.
制备了化学氧化阿拉伯胶，并将其用作天然衍生的无毒且pH响应性交联剂，首次用于开发基于智能聚乙烯醇（PVA）的水凝胶。所制备的水凝胶具有高机械性能、良好的孔隙率和pH敏感性，这有利于它们作为叶酸持续递送的有前景的生物材料的应用。此外，合成的交联PVA水凝胶对人胚肾细胞系无细胞毒性，并表现出更高的血液相容性。水解降解研究证实了它们的可生物降解性质。虽然这些水凝胶的持续递送以及光保护性能证实了它们的多功能特性，但这些结果表明这些水凝胶可能作为一种有效的光保护材料，并在药物递送领域找到其应用。
