Vashist Arti, Vashist Atul, Gupta Y K, Ahmad Sharif
Materials Research Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi, India.
J Mater Chem B. 2014 Jan 14;2(2):147-166. doi: 10.1039/c3tb21016b. Epub 2013 Nov 18.
The upsurge in the need of targeted controlled drug delivery (TCDD) has led to the invention of remarkable biomaterials with improved biocompatibility and biodegradability. In recent years, "Smart Polymers" have emerged as a potential candidate, competing with the existing hydrogel systems used for controlled drug delivery. This article is an effort to highlight the diverse applications of hydrogels for revolutionizing the present research on drug delivery systems. This article summarizes the role of hydrogels as delivery vehicles for drugs used in various disorders related to the brain and other distinct parts of the human body. The clinical application and toxicological aspects of hydrogels are also highlighted. Their potential for diagnostics and various therapeutic interventions against tuberculosis have been reviewed. In addition, the limitations and future prospectives in the development of biopolymeric hydrogels are discussed.
靶向控释给药（TCDD）需求的激增促使人们发明了具有更好生物相容性和生物降解性的卓越生物材料。近年来，“智能聚合物”已成为一种潜在的候选材料，与现有的用于控释给药的水凝胶系统展开竞争。本文旨在突出水凝胶在革新当前药物递送系统研究方面的多样应用。本文总结了水凝胶作为用于治疗人体大脑及其他不同部位各种疾病的药物递送载体的作用。还强调了水凝胶的临床应用和毒理学方面。对其在结核病诊断和各种治疗干预方面的潜力进行了综述。此外，还讨论了生物聚合物水凝胶开发中的局限性和未来前景。
