Tofiloska Valentina, Velik-Stefanovska Vesna, Dimitrov Goran
University Clinic for Gynecology and Obstetrics, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
Department of Epidemiology and Biostatistics, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
Open Access Maced J Med Sci. 2019 Jul 28;7(14):2263-2266. doi: 10.3889/oamjms.2019.639. eCollection 2019 Jul 30.
Postmenopausis is a period that starts one year after the last menstruation. Late menopause, after 70 years, is called senile.
To examine the correlation between endometrial thickness and the risk of endometrial malignancy in postmenopausal.
Prospective clinical study involving 120 postmenopausal patients treated at the University Clinic for Gynecology and Obstetrics - Skopje, divided into two groups: control and examination. The control group included 40 postmenopausal patients, hospitalised and operated due to urogenital pathology. The examined group consisted of 80 patients divided into three subgroups according to the ultrasound verified thickness of the endometrium: from 5-8 mm; > 8-11 mm and above 11 mm. A detailed history and intervention were taken in the patients from both groups, and the material was sent for histopathological analysis to determine eventual malignancy.
The probability of endometrial malignancy significantly increased by 1.012 times in the group with a thickness of the endometrium from 5-8 mm, 1.769 times in the endometrial thickness group > 8-11 mm and 4.737-fold in the group over 11 mm compared to the control group.
In postmenopausal patients, the likelihood of endometrial cancer significantly increases with the thickness of the endometrium.
绝经后期是指最后一次月经后开始的时期。70岁以后的绝经后期称为老年期。
研究绝经后子宫内膜厚度与子宫内膜恶性肿瘤风险之间的相关性。
前瞻性临床研究，涉及120例在斯科普里大学妇产科诊所接受治疗的绝经后患者，分为两组：对照组和检查组。对照组包括40例因泌尿生殖系统疾病住院并接受手术的绝经后患者。检查组由80例患者组成，根据超声检查证实的子宫内膜厚度分为三个亚组：5 - 8毫米；>8 - 11毫米和11毫米以上。对两组患者进行详细的病史询问和干预，并将材料送去进行组织病理学分析以确定是否存在恶性肿瘤。
与对照组相比，子宫内膜厚度为5 - 8毫米的组中子宫内膜恶性肿瘤的概率显著增加1.012倍，子宫内膜厚度>8 - 11毫米的组中增加1.769倍，11毫米以上的组中增加4.737倍。
在绝经后患者中，子宫内膜癌的可能性随着子宫内膜厚度的增加而显著增加。
