心脏过敏反应中白三烯释放及冠状动脉收缩效应的药理学调节

Pharmacological modification of leukotriene release and coronary constrictor effect in cardiac anaphylaxis.

作者信息

Weinerowski P, Wittmann G, Aehringhaus U, Peskar B A

出版信息

Adv Prostaglandin Thromboxane Leukot Res. 1985;13:47-50.

Abstract

The modification of anaphylactic release of leukotriene (LT) C4-like immunoreactivity from isolated guinea pig hearts and of LT-induced coronary constriction by the muscarinic receptor against methacholine and by various exogenous prostaglandins (PG) was investigated. The vasodilators PGI2 and PGE2 as well as the vasoconstrictors PGD2, PGF2alpha, and 11,9-epoxymethano-PGH2, a PG endoperoxide analogue with biological properties similar to thromboxane (TX) A2, inhibited the anaphylactic coronary constriction without affecting release of LTC4-like immunoreactivity. On the other hand, the increased anaphylactic LT release in the presence of methacholine was not paralleled by more pronounced coronary constriction after challenge. The results suggest that the coronary constrictor effect of endogenous LT is modified by the drugs used by direct vascular effects and/or effects on other anaphylactic mediators.

摘要

研究了毒蕈碱受体对豚鼠离体心脏白三烯（LT）C4样免疫反应性过敏释放的影响，以及各种外源性前列腺素（PG）对LT诱导的冠状动脉收缩的影响。血管舒张剂前列环素（PGI2）和前列腺素E2（PGE2）以及血管收缩剂前列腺素D2（PGD2）、前列腺素F2α（PGF2α）和11,9-环氧甲撑前列腺素H2（一种生物特性类似于血栓素（TX）A2的PG内过氧化物类似物）可抑制过敏性冠状动脉收缩，而不影响LTC4样免疫反应性的释放。另一方面，在乙酰甲胆碱存在下过敏性LT释放增加，但激发后冠状动脉收缩并未更明显。结果表明，内源性LT的冠状动脉收缩作用被所用药物通过直接血管效应和/或对其他过敏介质的效应所改变。