Dembinska-Kieć A, Simmet T, Peskar B A
Eur J Pharmacol. 1984 Jun 1;101(3-4):259-62. doi: 10.1016/0014-2999(84)90166-3.
Antigen challenge of sensitized isolated guinea-pig mesentery perfused under constant pressure resulted in a significant flow reduction, which was paralleled by the release of leukotriene (LT)C4-like immunoreactivity into the perfusates. The lipoxygenase inhibitor quercetin inhibited the release of immunoreactive LTC4 and simultaneously abolished the antigen-induced mesenteric flow reduction. Mesenteric flow reduction was also observed after injection of exogenous LTC4. The results demonstrate that LTC4 is a constrictor of the mesenteric vascular bed and that endogenous LTC4-like immunoreactive material is a mediator of anaphylactic vasoconstriction in the guinea-pig mesentery.
在恒压下灌注致敏的豚鼠离体肠系膜，抗原激发会导致血流显著减少，同时伴有白三烯（LT）C4样免疫反应性物质释放到灌流液中。脂氧合酶抑制剂槲皮素可抑制免疫反应性LTC4的释放，并同时消除抗原诱导的肠系膜血流减少。注射外源性LTC4后也观察到肠系膜血流减少。结果表明，LTC4是肠系膜血管床的收缩剂，内源性LTC4样免疫反应性物质是豚鼠肠系膜过敏性血管收缩的介质。
