Santonja Carlos, Prieto-Torres Lucía, Pérez-Sáenz María de Los Ángeles, Requena Luis, Rodríguez-Pinilla Socorro-María
Department of Pathology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.
Department of Dermatology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain; and.
Am J Dermatopathol. 2020 Mar;42(3):e36-e40. doi: 10.1097/DAD.0000000000001544.
We report on a 74-year-old man with a cutaneous B-cell follicle center lymphoma, which was treated upfront with systemic rituximab and suffered several local relapses. The first of the local recurrences, 10 months after completion of treatment, was characterized by a dense T-cell infiltrate that obscured a minor population of B-cell lymphoma cells, suggesting a second primary cutaneous T-cell lymphoma. This represents a previously not reported diagnostic pitfall and underscores the importance of performing sequential biopsies when dealing with lymphoma recurrences in this setting.
我们报告了一名74岁患有皮肤B细胞滤泡中心淋巴瘤的男性患者，该患者一开始接受了利妥昔单抗全身治疗，但出现了多次局部复发。首次局部复发发生在治疗结束10个月后，其特征是密集的T细胞浸润掩盖了少量B细胞淋巴瘤细胞，提示可能是第二种原发性皮肤T细胞淋巴瘤。这代表了一种此前未报道过的诊断陷阱，并强调了在这种情况下处理淋巴瘤复发时进行序贯活检的重要性。
