原发性皮肤滤泡中心淋巴瘤。
Primary Cutaneous Follicle Center Lymphoma.
机构信息
From the Department of Pathology, University of Michigan Medical Center, Ann Arbor (Drs Skala and A. C. Hristov); the Department of Internal Medicine, Section of Radiation Oncology, Wright Patterson Air Force Base (Dr B. Hristov); and the Department of Dermatology, University of Michigan Medical Center (Dr A. C. Hristov).
出版信息
Arch Pathol Lab Med. 2018 Nov;142(11):1313-1321. doi: 10.5858/arpa.2018-0215-RA.
CONTEXT.—: Primary cutaneous follicle center lymphoma is a low-grade B-cell lymphoma that is limited to the skin at diagnosis. It has a differential diagnosis that includes systemic/nodal follicular lymphoma secondarily involving the skin; primary cutaneous diffuse large B-cell lymphoma leg type; reactive lymphoid hyperplasia; and primary cutaneous marginal zone lymphoma.
OBJECTIVE.—: To review the clinical, morphologic, immunophenotypic, and genetic features of primary cutaneous follicle center lymphoma; its differential diagnosis; and the evidence that supports use of immunohistochemistry and genetic testing in the diagnosis and prognosis of this entity.
DATA SOURCES.—: Pertinent literature regarding cutaneous B-cell lymphomas is summarized and University of Michigan cases are used to highlight characteristics of primary cutaneous follicle center lymphoma.
CONCLUSIONS.—: Primary cutaneous follicle center lymphoma is a low-grade B-cell lymphoma with distinctive features, although some cases may have elements that overlap with other lymphomas, complicating interpretation.
背景
原发性皮肤滤泡中心淋巴瘤是一种低级别 B 细胞淋巴瘤，在诊断时局限于皮肤。其鉴别诊断包括系统/淋巴结滤泡性淋巴瘤继发累及皮肤；原发性皮肤弥漫性大 B 细胞淋巴瘤腿型；反应性淋巴组织增生；以及原发性皮肤边缘区淋巴瘤。
目的
回顾原发性皮肤滤泡中心淋巴瘤的临床、形态学、免疫表型和遗传学特征；其鉴别诊断；以及支持使用免疫组织化学和基因检测来诊断和预测该疾病的证据。
数据来源
对有关皮肤 B 细胞淋巴瘤的文献进行了总结，并使用密歇根大学的病例来突出原发性皮肤滤泡中心淋巴瘤的特征。
结论
原发性皮肤滤泡中心淋巴瘤是一种低级别 B 细胞淋巴瘤，具有独特的特征，尽管某些病例可能具有与其他淋巴瘤重叠的特征，从而使解释变得复杂。
Zotero 插件