From the Department of Physical Medicine and Rehabilitation, Hitit University Erol Olcok Training and Research Hospital, Corum, Turkey (YB-O); Division of Pain Medicine, Department of Physical Medicine and Rehabilitation, Marmara University Medical School, Istanbul, Turkey (GA); Department of Physical Medicine and Rehabilitation, Marmara University Medical School, Istanbul, Turkey (MK); and Division of Medical Oncology, Marmara University Medical School, Istanbul, Turkey (PFY).
Am J Phys Med Rehabil. 2020 Apr;99(4):291-299. doi: 10.1097/PHM.0000000000001324.
The aim of the study was to evaluate the effect of lower limb strengthening and balance exercises on balance, quality of life and neuropathic pain of the cancer patients receiving neurotoxic chemotherapy.
Patients who were planning to receive neurotoxic chemotherapy agents were included in the first group. They were trained before the neurotoxic chemotherapy sessions with the 10-wk home-based exercise program including lower limb strengthening and balance exercises. The second group of patients who had received the third cycle of neurotoxic chemotherapy had no exercise program. Both groups were evaluated after the third cycle. Neurocom Balance Master and Berg Balance Scale were used to evaluate balance. The neuropathic pain was questioned by PainDETECT questionnaire and the quality of life was assessed with the European Organization for Research and Treatment of Cancer's Quality of Life Questionnaire.
Sixty patients were admitted to this study. Twenty-four patients were in the exercise group (F = 14, M = 10) and 36 patients were in the control group (F = 17, M = 19). Sociodemographic and clinical data of both groups were similar. Berg Balance Scale (P = 0.005), European Organization for Research and Treatment of Cancer's Quality of Life Questionnaire global quality of life, physical function, and emotional status were higher, and symptom scores and PainDETECT questionnaire score were lower in the exercise group (P < 0.05). Balance tests were different between the groups.
Strengthening and balance exercises have a valuable effect on balance, quality of life, and neuropathic pain in patients receiving neurotoxic chemotherapy.
本研究旨在评估下肢力量训练和平衡练习对接受神经毒性化疗的癌症患者平衡、生活质量和神经病理性疼痛的影响。
计划接受神经毒性化疗药物的患者被纳入第一组。他们在接受神经毒性化疗前接受了为期 10 周的家庭锻炼计划，包括下肢力量训练和平衡练习。第二组患者已经接受了 3 个周期的神经毒性化疗，没有进行锻炼计划。两组患者均在第 3 个周期后进行评估。使用神经康平衡大师和伯格平衡量表评估平衡。通过疼痛 DETECT 问卷询问神经病理性疼痛，使用欧洲癌症研究与治疗组织生活质量问卷评估生活质量。
共有 60 名患者参与了这项研究。24 名患者在锻炼组（F=14，M=10），36 名患者在对照组（F=17，M=19）。两组的社会人口统计学和临床数据相似。伯格平衡量表（P=0.005）、欧洲癌症研究与治疗组织生活质量问卷总体生活质量、身体功能和情绪状况评分较高，而锻炼组症状评分和疼痛 DETECT 问卷评分较低（P<0.05）。两组的平衡测试结果不同。
强化和平衡练习对接受神经毒性化疗的患者的平衡、生活质量和神经病理性疼痛具有有益的影响。
