一项治疗性运动计划改善化疗期间周围神经病变症状的有效性：随机临床试验的系统评价
Effectiveness of a Therapeutic Exercise Program to Improve the Symptoms of Peripheral Neuropathy during Chemotherapy: Systematic Review of Randomized Clinical Trials.
作者信息
Dixit Snehil, Tapia Valentina, Sepúlveda Carolina, Olate Daniela, Berríos-Contreras Lily, Lorca Luz Alejandra, Alqahtani Abdulfattah S, Ribeiro Ivana Leão
机构信息
Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61471, Saudi Arabia.
Department of Kinesiology, Faculty of Healthy Sciences, Universidad Católica del Maule, Talca 3460000, Chile.
出版信息
Life (Basel). 2023 Jan 18;13(2):262. doi: 10.3390/life13020262.
BACKGROUND
Therapeutic exercise has an important role to manage chemotherapy-induced peripheral neuropathy symptoms. However, there is little evidence of its effectiveness.
OBJECTIVE
To synthesize the evidence regarding therapeutic exercise during chemotherapy to improve peripheral neuropathy symptoms.
DATABASES
PubMed, CINAHL, Cochrane Library, PEDro, ScienceDirect, Scopus, Web of Science and BIREME.
METHODOLOGY
Randomized clinical trials were included. GRADE was used to synthesize evidence and an inverse variance model for meta-analysis.
RESULTS
Up to May 2022, 2172 references were analyzed and 14 studies that evaluated 1094 participants were included. The exercises were highly effective in improving pain threshold and moderately effective in improving peripheral neuropathy symptoms at the 8-week follow-up and the 4-24 weeks. Furthermore, the evidence was low in improving thermal threshold, tactile and vibratory sensitivity.
CONCLUSION
Therapeutic exercise generates a significant reduction in peripheral neuropathy symptoms in patients in short- and long-term follow-up with a moderate level of evidence quality.
背景
治疗性运动在管理化疗引起的周围神经病变症状方面具有重要作用。然而，其有效性的证据很少。
目的
综合有关化疗期间治疗性运动改善周围神经病变症状的证据。
数据库
PubMed、CINAHL、Cochrane图书馆、PEDro、ScienceDirect、Scopus、科学网和BIREME。
方法
纳入随机临床试验。采用GRADE合成证据，并采用逆方差模型进行荟萃分析。
结果
截至2022年5月，共分析了2172篇参考文献，纳入了14项评估1094名参与者的研究。这些运动在改善疼痛阈值方面非常有效，在8周随访以及4 - 24周时改善周围神经病变症状方面中等有效。此外，在改善热阈值、触觉和振动敏感性方面证据不足。
结论
治疗性运动在短期和长期随访中能显著减轻患者周围神经病变症状，证据质量中等。
Zotero 插件