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实施简单门诊神经外科手术阿片类药物减量方案:单中心经验。

Implementation of an Opioid Reduction Protocol for Simple Outpatient Neurosurgical Procedures: A Single-Center Experience.

机构信息

Neuroscience Institute, Virginia Mason Medical Center, Seattle, WA.

Department of Neurosurgery, Virginia Mason Medical Center, Seattle, WA.

出版信息

Spine (Phila Pa 1976). 2020 Mar 15;45(6):397-404. doi: 10.1097/BRS.0000000000003272.

Abstract

STUDY DESIGN

Quality improvement with before and after evaluation of the intervention.

OBJECTIVE

To evaluate postoperative opioid utilization at a high-volume tertiary referral center following implementation of an opioid reduction protocol for simple outpatient neurosurgical procedures.

SUMMARY OF BACKGROUND DATA

The opioid epidemic has been well-publicized both in the scientific and lay press over the last few years. As a response to this crisis many state-wide and national medical groups have sought to develop opioid prescribing guidelines for both acute and chronic pain states. Some guidelines have studied opioid prescribing in orthopedic procedures but have primarily limited their recommendations to simple outpatient orthopedic joint procedures. Although, it is not clear that these opioid prescribing reductions are directly translatable to neurosurgical procedures.

METHODS

We implemented an opioid reduction protocol geared towards the postoperative management for simple outpatient neurosurgical procedures and measured the effect on number of pills and total morphine equivalent dose (MED) prescribed, postoperative readmissions, refill requests, and conversion to long-term opiate use.

RESULTS

Our study population was 246 patients, with 109 patients in the pre-intervention (PRE) group and 137 patients in the post-intervention (POST) group. The vast majority of patients in both groups were discharged with an opioid prescription (93% PRE, 91% POST, P = 0.87). The POST group had significantly lower total discharge opioid medication quantity (52 tabs PRE, 27 tabs POST, P < 0.001), discharge day MED (51.3 PRE, 45.3 POST, P = 0.01), and total discharge MED (287 PRE, 149 POST, P < 0.001).

CONCLUSION

A standardized discharge protocol for postoperative neurosurgery can lead to significant reductions in opioid discharge quantity without compromising patient safety or increasing the utilization of hospital resources through readmissions, refill requests, or clinic phone calls. This study provides an example of a feasible and effective discharge prescription regimen that may be generalizable to some of the most common outpatient neurosurgical procedures.

LEVEL OF EVIDENCE

摘要

研究设计

干预前后的质量改进评估。

目的

评估在高容量三级转诊中心实施简化门诊神经外科手术阿片类药物减少方案后,术后阿片类药物的使用情况。

背景资料总结

过去几年,阿片类药物流行在科学界和大众媒体中都得到了广泛报道。作为对此危机的回应,许多州和国家医疗团体都试图为急性和慢性疼痛状态制定阿片类药物处方指南。一些指南研究了骨科手术中的阿片类药物处方,但主要将建议仅限于简单的门诊骨科关节手术。然而,尚不清楚这些阿片类药物处方减少是否可以直接转化为神经外科手术。

方法

我们实施了一项针对简化门诊神经外科手术术后管理的阿片类药物减少方案,并测量了对所开药片数量和总吗啡等效剂量(MED)、术后再入院、药物续开请求以及转为长期阿片类药物使用的影响。

结果

我们的研究人群为 246 名患者,其中 109 名患者在干预前(PRE)组,137 名患者在干预后(POST)组。两组中绝大多数患者出院时都开具了阿片类药物处方(93% PRE,91% POST,P=0.87)。POST 组出院时的总阿片类药物用量明显较低(52 片 PRE,27 片 POST,P<0.001),出院日 MED(51.3 PRE,45.3 POST,P=0.01)和总出院 MED(287 PRE,149 POST,P<0.001)。

结论

针对神经外科术后的标准化出院方案可以显著减少阿片类药物的出院用量,同时不影响患者安全或通过再入院、药物续开请求或诊所电话增加医院资源的利用。本研究提供了一个可行且有效的出院处方方案的实例,该方案可能适用于一些最常见的门诊神经外科手术。

证据水平

3 级。

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