三（1-金刚烷基）膦实现的钯催化烯醇酯级联芳基化反应
Palladium-Catalyzed Cascade Arylation of Vinylogous Esters Enabled by Tris(1-adamantyl)phosphine.
作者信息
Yang Yi-Chi, Lin Yi-Ching, Wu Yen-Ku
机构信息
Department of Applied Chemistry , National Chiao Tung University , 1001 University Road , Hsinchu 30010 , Taiwan.
出版信息
Org Lett. 2019 Dec 6;21(23):9286-9290. doi: 10.1021/acs.orglett.9b03071. Epub 2019 Oct 8.
PMID:31593479
Abstract
Described is a method for the transformation of a cyclic vinylogous ester to the corresponding polyarylated product. We found a catalytic system comprising palladium diacetate and tris(1-adamantyl)phosphine is quite effective in promoting a set of controlled cascade arylations. As a result, a range of novel (hetero)aryl-containing scaffolds was synthesized with a high level of efficiency.
摘要
描述了一种将环状乙烯基酯转化为相应的多芳基化产物的方法。我们发现，由二乙酸钯和三（1-金刚烷基）膦组成的催化体系在促进一系列可控的级联芳基化反应方面非常有效。结果，高效地合成了一系列新型的含（杂）芳基的支架。
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