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[强直性脊柱炎的心脏受累情况]

[Cardiac involvement in ankylosing spondylitis].

作者信息

Pop G, Romero-Ayala L C, Bialostozky D, Medrano G A, Martínez Lavín M

出版信息

Arch Inst Cardiol Mex. 1985 Jan-Feb;55(1):63-7.

PMID:3159361
Abstract

Ankylosing spondylitis is a rheumatic disease that affects the axial skeleton and has predilection for young men. Of its extraarticular manifestations, the cardiac involvement, reported up to 48%, has been pointed out in recent years. It seems to exist a racial variation in the features of the spondylitis and since most of the studies have been performed in northern countries therefore it appears inadequate to extrapolate the conclusions of such studies to our society. We studied 23 patients with definitive diagnosis of ankylosing spondylitis. All of them had a complete physical examination, electrocardiography and X-ray of the chest; eight patients underwent a Holter study of 24 hours and seven patients were examined by echocardiography. The mean age of the group was 36 years; there were 21 men and two women. The mean duration of the rheumatic disease was 11.5 years. In only 4 (17.4%) of the patients we found cardiac involvement that would not be related to another etiology. By the clinic examination we found two patients with isolated aortic insufficiency; one case had a right bundle branch block. The Holter study did not show modifications, except in the one with isolated aortic insufficiency and right bundle branch block, in whom this block became of variable degree. The echocardiographic study showed the mentioned aortic valvular lesions and did reveal the same lesion in another patient in which the other studies were normal. It is emphasized that it is adequate to search for signs of ankylosing spondylitis in every patient with isolated aortic insufficiency or/and conduction disturbances of unknown etiology and also to performe cardiac careful in each patient with ankylosing spondylitis examination.

摘要

强直性脊柱炎是一种影响中轴骨骼的风湿性疾病,好发于青年男性。在其关节外表现中,心脏受累情况近年来受到关注,报告显示发生率高达48%。强直性脊柱炎的特征似乎存在种族差异,且由于大多数研究是在北方国家进行的,因此将这些研究结论外推至我们的社会似乎并不合适。我们研究了23例确诊为强直性脊柱炎的患者。所有患者均接受了全面的体格检查、心电图检查和胸部X线检查;8例患者进行了24小时动态心电图监测,7例患者接受了超声心动图检查。该组患者的平均年龄为36岁;其中男性21例,女性2例。风湿性疾病的平均病程为11.5年。仅4例(17.4%)患者发现心脏受累且与其他病因无关。通过临床检查,我们发现2例患者存在单纯主动脉瓣关闭不全;1例患者有右束支传导阻滞。动态心电图监测未发现异常改变,除了1例单纯主动脉瓣关闭不全合并右束支传导阻滞的患者,其右束支传导阻滞程度出现变化。超声心动图检查显示了上述主动脉瓣病变,并且在另一例其他检查正常的患者中也发现了相同病变。需要强调的是,对于每例病因不明的单纯主动脉瓣关闭不全或/和传导障碍患者,均应寻找强直性脊柱炎的体征,对于每例强直性脊柱炎患者也应进行仔细的心脏检查。

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