Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, CNRS UMR 5242, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, CNRS UMR 5242, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Arch Oral Biol. 2020 Jan;109:104576. doi: 10.1016/j.archoralbio.2019.104576. Epub 2019 Sep 27.
Dental development mechanisms in mammals are highly studied using the mouse as a biological model. However, the mouse has a single, unreplaced, set of teeth. Features of mammalian tooth replacement are thus poorly known. In this paper, we study mammalian tooth development and replacement using the European rabbit, Oryctolagus cuniculus, as a new model. Using 3D-reconstructions associated with histological sections, we obtained the complete description of the histo-morphological chronology of dental development and replacement in rabbit. We also describe in the dentin the presence of holes opening the pulp cavity in newborns. These holes are quickly repaired with a new and fast apposition of dentin from the pre-existing odontoblasts. The detailed dental morphogenesis chronology presented allows us to propose the rabbit Oryctolagus cuniculus as a suitable model to study mammalian tooth replacement.
哺乳动物的牙齿发育机制是通过以老鼠作为生物模型来进行深入研究的。然而，老鼠只有一套不可替代的牙齿。因此，哺乳动物牙齿替换的特征鲜为人知。在本文中，我们使用欧洲兔（Oryctolagus cuniculus）作为一种新模型来研究哺乳动物的牙齿发育和替换。通过与组织学切片相关的 3D 重建，我们获得了兔子牙齿发育和替换的组织形态学时间进程的完整描述。我们还在新生兔的牙本质中描述了牙髓腔开口的孔。这些孔很快就会被新的、快速的牙本质修复，这些牙本质是由预先存在的成牙本质细胞形成的。呈现的详细牙齿形态发生时间进程使我们能够提出兔（Oryctolagus cuniculus）作为研究哺乳动物牙齿替换的合适模型。
