Boschetti C, Cortellaro M, Invernizzi F, Massaro P, Rigolone A, Polli E
Boll Ist Sieroter Milan. 1985;64(1):55-8.
Platelet production time (PPT), circulating platelet aggregates (CPA ratio) and plasma beta-thromboglobulin (beta TG) were determined in patients with essential mixed cryoglobulinemia (EMC) before and after two months' treatment with sulfinpyrazone. Sulfinpyrazone determined a clinical improvement in 8 of the 16 patients. Basal PPT and CPA ratio were reduced compared with normal values but not significantly; after sulfinpyrazone treatment both PPT and CPA ratio increased to normal levels. High plasma beta TG levels were found before and after treatment. These data suggest that in some cases of EMC there is a picture of in vivo platelet activation, but with the small number of patients it was not possible to evaluate a possible correlation between platelet hyperactivity and the clinical picture.
在原发性混合性冷球蛋白血症（EMC）患者中，于使用苯磺唑酮治疗两个月前后，测定了血小板生成时间（PPT）、循环血小板聚集体（CPA比率）和血浆β-血小板球蛋白（βTG）。在16例患者中，有8例经苯磺唑酮治疗后临床症状改善。基础PPT和CPA比率与正常值相比有所降低，但无显著差异；苯磺唑酮治疗后，PPT和CPA比率均升至正常水平。治疗前后均发现血浆βTG水平较高。这些数据表明，在某些EMC病例中存在体内血小板活化的情况，但由于患者数量较少，无法评估血小板活性过高与临床症状之间可能存在的相关性。
