阉割后仓鼠精囊中的分泌细胞活性。一项形态计量超微结构研究。

Secretory cell activity in the hamster seminal vesicle following castration. A morphometric ultrastructural study.

作者信息

Mata L R, David-Ferreira J F

出版信息

Biol Cell. 1985;53(2):165-77. doi: 10.1111/j.1768-322x.1985.tb00364.x.

DOI:10.1111/j.1768-322x.1985.tb00364.x

Abstract

The ultrastructure of hamster seminal vesicle epithelium was studied 7, 14, 21 and 28 days after castration using a stereological approach. The results show that castration promotes epithelial reorganization, mainly characterized by reduced epithelial cell size and number, decreased rough endoplasmic reticulum and Golgi complex, increased lysosomes and lipid droplets, increased apical secretory granule size and number, and increased intracellular secretory products per average epithelial cell. It is concluded that after testosterone withdrawal the secretory activity of hamster seminal vesicle epithelial cells, although reduced, is not abolished, and that exocytosis is relatively more reduced than secretory protein production. We suggest that an extracellular androgen source is responsible for secretory activity not being lost in the epithelial cells of castrated hamster seminal vesicle.

摘要

采用体视学方法，研究了去势后7、14、21和28天的仓鼠精囊上皮超微结构。结果表明，去势促进上皮细胞重组，主要表现为上皮细胞大小和数量减少、粗面内质网和高尔基体减少、溶酶体和脂滴增加、顶端分泌颗粒大小和数量增加以及每个平均上皮细胞的细胞内分泌产物增加。得出的结论是，睾酮撤除后，仓鼠精囊上皮细胞的分泌活性虽降低但未消除，且胞吐作用相对分泌蛋白产生减少得更多。我们认为，细胞外雄激素源是去势仓鼠精囊上皮细胞分泌活性未丧失的原因。