Spring-Mills E, Krall A, Apellaniz M
Arch Androl. 1982 Nov;9(3):203-13. doi: 10.3109/01485018208990240.
The effects of prolactin (PRL) and androgen on the seminal vesicles of immature C3H/HeJ mice were studied. Glands from controls exhibited secretory activity and full differentiation. Glands from castrates were small, markedly atrophic with some stromal hyperplasia and moderate leukocytic infiltration. Testosterone-treated castrates were similar to intact controls. Perphenazine appeared to stimulate the rough endoplasmic reticulum (RER), Golgi, and secretory activity of the epithelium in the intact and castrated mice. Normal secretory granules were not made in the perphenazine-treated castrates, but a flocculent material usually was present in the RER, Golgi, and secretory vacuoles. Bromocriptine reduced cell height and secretory activity in intact mice and promoted anaplasia and epithelial proliferation in castrates. PRL seems to be required for the seminal vesicles to complete and maintain cytological development, but the effect of PRL may be different in the presence or absence of testicular androgens.
研究了催乳素（PRL）和雄激素对未成熟C3H/HeJ小鼠精囊的影响。对照组的腺体表现出分泌活性和完全分化。去势小鼠的腺体较小，明显萎缩，伴有一些间质增生和中度白细胞浸润。睾酮处理的去势小鼠与完整对照组相似。奋乃静似乎能刺激完整和去势小鼠上皮细胞的粗面内质网（RER）、高尔基体及分泌活性。在经奋乃静处理的去势小鼠中未形成正常的分泌颗粒，但RER、高尔基体和分泌泡中通常存在絮状物质。溴隐亭可降低完整小鼠的细胞高度和分泌活性，并促进去势小鼠的退行发育和上皮细胞增殖。精囊似乎需要PRL来完成并维持细胞学发育，但PRL在有或无睾丸雄激素存在时的作用可能不同。
