Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine Faculty of Epidemiology and Population Health, London, UK.
Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine Faculty of Epidemiology and Population Health, London, UK
BMJ Open. 2019 Oct 7;9(10):e031867. doi: 10.1136/bmjopen-2019-031867.
Human herpesviruses induce lifelong latent infections and may reactivate as the immune system deteriorates. Recent studies have suggested that vitamin D, an essential element of bone health, may have some effect of protecting against infections, but investigations of its potential to prevent herpesvirus infection or reactivation are limited. We will review the current literature examining vitamin D and the risk of herpesvirus infections or reactivation.
Our systematic review will address two research questions: (1) Do deficient/insufficient serum vitamin D levels increase the risk of herpesvirus infections and (2) Does vitamin D supplementation protect against herpesvirus infections? We will include only intervention studies with control groups, cohort studies and case-control studies. We will use subject headings and keywords to search for synonyms of 'vitamin D' and 'herpesviruses' (including herpes simplex virus type 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus and human herpesviruses type 6, 7 and 8) in Medline, Embase, Global Health, Web of Science, Scopus and Cochrane Central Register of Controlled Trials, and the grey literature databases Open Grey, EThOS and BASE from inception to 31 August 2019. References to the included articles and relevant systematic reviews will also be examined. Two reviewers will independently screen the study titles and abstracts, and examine the full texts to decide the final eligibility. They will independently extract data from the studies and assess bias using the Cochrane Collaboration approach. A third researcher will solve any discrepancies. The results will be narratively synthesised; if an adequate number of studies is included and the homogeneity between studies is acceptable, a meta-analysis will be performed. We will assess the quality of evidence using the Grading of Recommendations, Assessment, Development and Evaluation framework, and display the results in a summary of findings table.
Ethical review is not required for a systematic review. We will publish the results in a peer-review journal. Any amendments to the protocol will be recorded in the supplementary section.
CRD42019130153.
人类疱疹病毒会导致终身潜伏感染，并可能随着免疫系统的恶化而重新激活。最近的研究表明，维生素 D 是骨骼健康的重要元素，它可能对预防感染有一定的作用，但关于其预防疱疹病毒感染或再激活的潜力的研究还很有限。我们将回顾目前研究维生素 D 与疱疹病毒感染或再激活风险的文献。
我们的系统综述将解决两个研究问题：（1）血清维生素 D 水平不足/缺乏是否会增加疱疹病毒感染的风险，（2）维生素 D 补充剂是否能预防疱疹病毒感染？我们将只纳入有对照组的干预研究、队列研究和病例对照研究。我们将使用主题词和关键词搜索 Medline、Embase、全球健康、Web of Science、Scopus 和 Cochrane 对照试验中心注册库中“维生素 D”和“疱疹病毒”（包括单纯疱疹病毒 1 型和 2 型、水痘-带状疱疹病毒、巨细胞病毒、EB 病毒和人类疱疹病毒 6、7 和 8 型）的同义词，并检索 Open Grey、EThOS 和 BASE 等灰色文献数据库，检索时间从建库到 2019 年 8 月 31 日。还将查阅纳入文章的参考文献和相关系统综述。两位评审员将独立筛选研究标题和摘要，并检查全文以确定最终的合格性。他们将独立从研究中提取数据，并使用 Cochrane 协作方法评估偏倚。第三位研究人员将解决任何差异。结果将以叙述的方式进行综合；如果纳入足够数量的研究，且研究之间的同质性可以接受，将进行荟萃分析。我们将使用推荐、评估、开发和评估框架（Grading of Recommendations, Assessment, Development and Evaluation framework）评估证据质量，并在“发现总结表”中展示结果。
系统综述不需要伦理审查。我们将在同行评议期刊上发表研究结果。如有对方案的任何修订，将记录在补充部分。
PROSPERO 注册号：CRD42019130153。
