Department of Psychiatry, New York University Medical Center, New York, NY, USA.
Department of Psychiatry, Center for the Treatment and Study of Anxiety, University of Pennsylvania, Philadelphia, PA, USA.
J Neuroendocrinol. 2020 Jan;32(1):e12800. doi: 10.1111/jne.12800. Epub 2019 Dec 3.
The accumulating evidence regarding the impact of estradiol on learning and memory synergized studies to examine its influence on enhancing animal's ability to quell fear and anxiety. In this review, we first provide a foundational platform regarding the impact of oestradiol on cellular mechanisms of learning and memory and we review recent advances from rodent and human data showing that oestrogen enhances extinction learning across species. We then propose clinical application to these data. We discuss the potential role of oestradiol variance on the aetiology, maintenance and treatment for post-traumatic stress disorder. Specifically, we argue that the use of oestradiol as an adjunct to prolonged exposure (PE) therapy for PTSD may provide a new treatment approach for enhancing the efficacy of PE in women with PTSD. This could advance our understanding of the mechanisms of PTSD and help tailor sex-specific treatments for this disorder.
越来越多的证据表明，雌二醇对学习和记忆有影响，这促使研究人员研究它对增强动物抑制恐惧和焦虑能力的影响。在这篇综述中，我们首先提供了一个关于雌二醇对学习和记忆的细胞机制的影响的基础平台，我们回顾了来自啮齿动物和人类数据的最新进展，这些数据表明雌激素增强了跨物种的消退学习。然后我们将这些数据应用于临床。我们讨论了雌二醇变异在创伤后应激障碍的发病机制、维持和治疗中的潜在作用。具体来说，我们认为将雌二醇作为延长暴露（PE）治疗创伤后应激障碍的辅助手段，可能为增强 PTSD 女性中 PE 的疗效提供一种新的治疗方法。这可以增进我们对 PTSD 机制的理解，并有助于为这种疾病制定针对性别的治疗方法。
