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预防新机器人手术出院患者开具过量麻醉处方:宾夕法尼亚大学前瞻性队列质量改进倡议。

Preventing Excess Narcotic Prescriptions in New Robotic Surgery Discharges: The PENN Prospective Cohort Quality Improvement Initiative.

机构信息

Division of Urology, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania.

出版信息

J Endourol. 2020 Jan;34(1):48-53. doi: 10.1089/end.2019.0362. Epub 2019 Nov 8.

Abstract

To reduce the amount of opioids prescribed at discharge after robotic surgery, we hypothesized that the majority patients do not require opioids for pain control after robotic urologic oncologic procedures. This prospective study aimed to reduce opioids prescribed at discharge after robot-assisted radical prostatectomy (RARP), robot-assisted radical nephrectomy (RARN), and robot-assisted partial nephrectomy (RAPN). Before 9/2018, 100% of patients were discharged on varying amounts of oxycodone (range: 75-337.5 oral morphine milligram equivalents [MME]). We implemented a standardized nonopioid analgesia pathway with escalation options (Fig. 1). To assess the safety of our approach, we analyzed pain scores, telephone encounters, and emergency department visits in our cohort. Our cohort ( = 170) consisted of patients undergoing RARP ( = 87), RARN ( = 25), and RAPN ( = 58) between September 2018 and January 2019. Overall, 67.7% were discharged without opioids, 24.4% with 10 pills of tramadol (50 MME), and 8.2% with 10 pills of oxycodone (75 MME). On multivariable analysis, older age (odds ratio: 0.961, 95% confidence interval: 0.923-0.995,  = 0.026) was associated with lower odds of needing opioids at discharge. There was no difference in pain scores at the postoperative outpatient visit ( = 0.66) or postoperative telephone encounters ( = 0.45) between those discharged with and without opioids. The majority of robotic surgery patients do not require opioids upon discharge. Implementation of a simple, standardized nonopioid protocol resulted in a dramatic reduction in the amount of opioids prescribed in our patient population. An escalation protocol allows for a patient-centered approach to reduce narcotic prescribing, although still addressing surgical pain.

摘要

为了减少机器人手术后出院时开具的阿片类药物的数量,我们假设大多数患者在机器人泌尿科肿瘤学手术后不需要阿片类药物来控制疼痛。这项前瞻性研究旨在减少机器人辅助根治性前列腺切除术(RARP)、机器人辅助根治性肾切除术(RARN)和机器人辅助部分肾切除术(RAPN)后出院时开具的阿片类药物的数量。在 2018 年 9 月之前,100%的患者出院时开具了不同剂量的羟考酮(范围:75-337.5 口服吗啡毫克当量 [MME])。我们实施了一种标准化的非阿片类镇痛药途径,并提供了升级选择(图 1)。为了评估我们方法的安全性,我们分析了我们队列中的疼痛评分、电话咨询和急诊就诊情况。我们的队列( = 170)包括 2018 年 9 月至 2019 年 1 月期间接受 RARP( = 87)、RARN( = 25)和 RAPN( = 58)的患者。总体而言,67.7%的患者出院时未开具阿片类药物,24.4%的患者开具了 10 片曲马多(50 MME),8.2%的患者开具了 10 片羟考酮(75 MME)。多变量分析显示,年龄较大(优势比:0.961,95%置信区间:0.923-0.995, = 0.026)与出院时需要阿片类药物的可能性较低相关。在术后门诊就诊( = 0.66)或术后电话咨询( = 0.45)时,出院时开具和未开具阿片类药物的患者之间的疼痛评分没有差异。大多数机器人手术患者出院时不需要阿片类药物。实施一种简单、标准化的非阿片类药物方案可显著减少我们患者群体中开具的阿片类药物数量。升级方案允许采取以患者为中心的方法来减少阿片类药物的开具,尽管仍需解决手术疼痛问题。

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