Hypascyrins A-E，来自. 的prenylated acylphloroglucinols

Hypascyrins A-E, Prenylated Acylphloroglucinols from .

机构信息

Graduate School of Pharmaceutical Sciences , Tokushima University , Tokushima 770-8505 , Japan.

Division of Immunobiology, Department of Pharmaceutical Sciences , International University of Health and Welfare , Tochigi 324-8501 , Japan.

出版信息

J Nat Prod. 2019 Oct 25;82(10):2754-2760. doi: 10.1021/acs.jnatprod.9b00354. Epub 2019 Oct 9.

DOI:10.1021/acs.jnatprod.9b00354

PMID:31596079

Abstract

Six new prenylated acylphloroglucinols with menthane moieties, hypascyrins A-E (-) and -hyphenrone J (), together with four known analogues, were isolated from roots. Detailed spectroscopic data analyses resulted in the assignment of their structures. The absolute configuration of was deduced by experimental and calculated ECD data, while those of - were assigned by ECD data analyses as well as chemical conversions. Hypascyrins A (), C (), and E () and -hyphenrone J () exhibited antimicrobial activity against MRSA (MIC values of 4.0, 8.0, 2.0, and 4.0 μM, respectively) and (MIC values of 4.0, 4.0, 2.0, and 4.0 μM, respectively).

摘要

从根部分离得到了六个具有薄荷烷部分的新的prenylated acylphloroglucinols，hypascyrins A-E (-) 和 -hyphenrone J (), 以及四个已知类似物。详细的光谱数据分析导致了它们结构的分配。通过实验和计算 ECD 数据推导出的绝对构型，而通过 ECD 数据分析以及化学转化确定了 - 的构型。Hypascyrins A (), C (), 和 E () 和 -hyphenrone J () 对 MRSA (MIC 值分别为 4.0、8.0、2.0 和 4.0 μM) 和 (MIC 值分别为 4.0、4.0、2.0 和 4.0 μM) 表现出抗菌活性。