University of Oklahoma Health Sciences Center, Department of Periodontics, Oklahoma City, OK, USA.
University of Michigan School of Dentistry, Department of Periodontics and Oral Medicine, Ann Arbor, MI, USA.
J Appl Oral Sci. 2019 Oct 7;27:e20180584. doi: 10.1590/1678-7757-2018-0584. eCollection 2019.
This study aimed to compare two different soft tissue replacement grafts in their ability to treat gingival recession defects and successfully integrate with the surrounding tissues.
Nine beagle dogs were included and followed up to 10 weeks. Sites for intervention were allocated to one of the grafting materials investigated. Treatment consisted of coronally advanced flap combined with one of the two soft tissue substitutes on a previous surgically created defect. Materials employed were porcine-derived acellular dermal matrix (ADM) [Novomatrix™ (Test)] and collagen-based matrix (CBM) [Mucograft® (Control)]. Animals were sacrificed at 2, 6, and 10 weeks postoperatively and compared using descriptive histology and histomorphometric outcomes.
Macroscopic findings were similar between test and control groups at all intervals. After 10 weeks, both groups demonstrated successful incorporation of the grafting materials without signs of rejection and with comparable tissue integration. The histomorphometric data were similar between groups at 2 weeks; however, the test group provided greater root coverage and increase in tissue thickness than the control at 6- and 10-weeks post surgically.
Both porcine-derived ADM and CBM revealed similar histological outcomes with successful integration and absence of adverse events. Test group provided superior outcomes regarding root coverage and increase in tissue thickness.
本研究旨在比较两种不同的软组织替代移植物在治疗牙龈退缩缺陷和与周围组织成功整合方面的能力。
纳入 9 只比格犬，随访 10 周。干预部位分配到所研究的两种移植物材料之一。治疗包括冠向推进瓣联合两种软组织替代物之一，用于先前手术创建的缺损。使用的材料为猪源性去细胞真皮基质（ADM）[Novomatrix™（测试）]和基于胶原的基质（CBM）[Mucograft®（对照）]。动物在术后 2、6 和 10 周时被处死，并通过描述性组织学和组织形态计量学结果进行比较。
在所有时间点，测试组和对照组的宏观发现均相似。术后 10 周，两组均成功整合了移植物材料，无排斥迹象，组织整合情况相似。两组在 2 周时的组织形态计量数据相似；然而，与对照组相比，实验组在术后 6 周和 10 周时提供了更大的根覆盖和组织厚度增加。
猪源性 ADM 和 CBM 均显示出相似的组织学结果，具有成功的整合和无不良反应。实验组在根覆盖和组织厚度增加方面提供了更好的结果。
