Inova Translational Medicine Institute, Falls Church, VA.
Inova Children's Hospital, Falls Church, VA.
Child Obes. 2020 Jan;16(1):59-64. doi: 10.1089/chi.2019.0055. Epub 2019 Oct 9.
Understanding the influence of genetically determined ancestry may give insight into the disparities of obesity seen in different ethnic groups beginning at a very early age. To investigate the relationship between children's ancestral genetic proportions and excess weight at 12 months of age. Eight hundred twenty-one 12-month-old children were included in this cross-sectional study. Their genetic admixture was estimated using the ancestry and kinship tool kit by projecting the samples into the 1000 Genomes principal component database. Weight-for-length percentile (WFLP) at 12 months of age was categorized as <95th percentile or ≥95th percentile. Multiple logistic regression analysis was performed to calculate odds ratios (ORs) with 95% confidence intervals (CIs) for the association of admixture proportions, including European (EUR), admixed American (AMR), African (AFR), South Asian (SAS), and East Asian (EAS) populations, with WFLP categories, adjusting for maternal education, birth weight, frequency of breastfeeding, and juice consumption. Eight hundred twenty-one children were included; WFLP <95th percentile = 671 (81.7%) and WFLP ≥95th percentile = 150 (18.3%). Crude ORs showed that the EUR admixture was protective [OR 0.45 (95% CI 0.27-0.74)], whereas AMR [OR 3.85 (95% CI 1.92-7.70)] and AFR [OR 5.70 (95% CI 2.19-14.85)] admixtures were positively associated with excess weight. After adjusting for confounding variables, only the AFR admixture was associated with WFLP ≥95th percentile [OR 7.38 (95% CI 2.31-23.59)]. AFRs remain associated with early excess weight after accounting for confounding variables, suggesting that this ancestral genetic background may contribute to the differences seen in early childhood obesity.
了解遗传决定的祖先的影响可能有助于深入了解不同种族群体在很小的时候就出现的肥胖差异。研究儿童祖先遗传比例与 12 个月时超重的关系。本横断面研究纳入了 821 名 12 个月大的儿童。使用祖先和亲属工具包通过将样本投影到 1000 基因组主成分数据库中，估计他们的遗传混合比例。12 个月时的体重-长度百分位数（WFLP）分为<95 百分位或≥95 百分位。进行多因素逻辑回归分析，计算混合比例（包括欧洲人（EUR）、混合美洲人（AMR）、非洲人（AFR）、南亚人（SAS）和东亚人（EAS））与 WFLP 分类的比值比（OR）及其 95%置信区间（CI），调整混杂因素包括母亲教育、出生体重、母乳喂养频率和果汁摄入量。纳入 821 名儿童；WFLP<95 百分位=671（81.7%），WFLP≥95 百分位=150（18.3%）。OR 显示 EUR 混合比例具有保护作用[OR 0.45（95%CI 0.27-0.74）]，而 AMR[OR 3.85（95%CI 1.92-7.70）]和 AFR[OR 5.70（95%CI 2.19-14.85）]混合比例与超重呈正相关。调整混杂因素后，只有 AFR 混合比例与 WFLP≥95 百分位相关[OR 7.38（95%CI 2.31-23.59）]。在考虑混杂因素后，AFR 仍然与早期超重相关，这表明这种祖先遗传背景可能导致儿童早期肥胖的差异。
