Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA; Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA.
Trends Genet. 2019 Nov;35(11):785-787. doi: 10.1016/j.tig.2019.09.001. Epub 2019 Oct 6.
DNA methylation regulates the organization and function of the genome. Yamanaka et al. now report that de novo methylation of male germ cells of mice involves the transient opening of heterochromatin at megabase-size differentially accessible domains (DADs). This chromatin remodeling likely facilitates de novo methylation of the germ cell genome.
DNA 甲基化调节基因组的组织和功能。Yamanaka 等人现在报告说，小鼠生殖细胞的从头甲基化涉及在兆碱基大小的差异可及域（DAD）处异染色质的瞬时开放。这种染色质重塑可能有助于生殖细胞基因组的从头甲基化。
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