Gajos Jamie M, Russell Michael A, Cleveland H Harrington, Vandenbergh David J, Feinberg Mark E
The Methodology Center, The Pennsylvania State University University Park, PA.
The Bennett Pierce Prevention Research Center, The Pennsylvania State University University Park, PA.
J Contemp Crim Justice. 2019 Feb;35(1):7-20. doi: 10.1177/1043986218810578. Epub 2018 Nov 8.
Previous research has identified the importance of romantic partners-including spouses, significant others, and dating partners-for influencing the engagement in health-risking behaviors, such as alcohol misuse during emerging adulthood. Although genetic factors are known to play a role in the development of young adult alcohol misuse, little research has examined whether genetic factors affect young adults' susceptibility to their romantic partners' alcohol misusing behaviors. The current study tests whether a single nucleotide polymorphism in the gene (rs279845) moderates the relationship between romantic partner alcohol misuse and frequency of drunkenness in young adulthood. Results revealed differential risk associated with romantic partner alcohol misuse and young adult drunk behavior according to genotype, such that individuals with the TT genotype displayed an elevated risk for frequency of drunkenness when romantic partner alcohol misuse was also high (IRR = 1.06, ≤ 0.05). The findings demonstrate the potential for genetic factors to moderate the influence of romantic partners' alcohol misuse on drunk behavior during the transition to young adulthood.
先前的研究已经确定了恋爱伴侣（包括配偶、重要他人和约会对象）在影响健康风险行为方面的重要性，比如在成年初期的酒精滥用。虽然已知遗传因素在青少年酒精滥用的发展过程中起作用，但很少有研究探讨遗传因素是否会影响青少年对其恋爱伴侣酒精滥用行为的易感性。当前的研究测试了基因（rs279845）中的单核苷酸多态性是否会调节恋爱伴侣酒精滥用与成年初期醉酒频率之间的关系。结果显示，根据基因型，恋爱伴侣酒精滥用与青少年醉酒行为存在不同的风险，即当恋爱伴侣酒精滥用程度也很高时，TT基因型个体的醉酒频率风险升高（风险比=1.06，P≤0.05）。研究结果表明，在向成年初期过渡期间，遗传因素有可能调节恋爱伴侣酒精滥用对醉酒行为的影响。
