Li Yingfu, Liu Shuyuan, Hong Chao, Ma Qianli, Tan Fang, Liu Chengxiu, Kuśnierczyk Piotr, Li Chuanyin, Shi Li, Yao Yufeng
Department of Geriatrics, The No.1 Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China.
J Cancer. 2019 Aug 20;10(20):4731-4738. doi: 10.7150/jca.33566. eCollection 2019.
The host immune system plays a crucial role in the surveillance, recognition and elimination of tumor cells. Recent studies found that Human lymphocyte antigen class I () genes, Killer cell immunoglobulin-like receptor () genes and combinations play a role in the defense against tumor cells. To evaluated the associations between genes, genes and combinations and non-small cell lung cancer (NSCLC) in a Chinese Han population, a total of 229 patients with NSCLC (adenocarcinoma) and 217 healthy individuals were studied. Our results showed that the allele occurred at a significantly higher frequency in the NSCLCs compared with the controls (=0.034). The haplotype frequencies bearing , , and loci between the NSCLC and control groups were not different (>0.05). And there were no differences in the gene, genotype and haplotype frequencies between the NSCLC and control groups (>0.05). Also, there were no differences between the combinations in the genes and , ligands and genes and HLA-C1/C2 ligands between the NSCLC and control groups (>0.05). Our results indicate that the allele could be a risk factor for NSCLC (adenocarcinoma) in the Chinese Han population (OR=2.395; 95% CI: 1.359-4.221).
宿主免疫系统在肿瘤细胞的监测、识别和清除中起着关键作用。最近的研究发现，人类白细胞抗原I类（）基因、杀伤细胞免疫球蛋白样受体（）基因及其组合在抵御肿瘤细胞方面发挥作用。为了评估在中国汉族人群中这些基因、基因及其组合与非小细胞肺癌（NSCLC）之间的关联，共研究了229例NSCLC患者（腺癌）和217名健康个体。我们的结果显示，与对照组相比，NSCLC患者中该等位基因的出现频率显著更高（=0.034）。NSCLC组和对照组之间携带、、和位点的单倍型频率没有差异（>0.05）。并且NSCLC组和对照组之间基因、基因型和单倍型频率也没有差异（>0.05）。此外，NSCLC组和对照组之间基因与、配体与基因以及HLA-C1/C2配体之间的组合也没有差异（>0.05）。我们的结果表明，该等位基因可能是中国汉族人群中NSCLC（腺癌）的一个危险因素（OR=2.395；95%CI：1.359 - 4.221）。
