The association of genes with non-small cell lung cancer (adenocarcinoma) in a Han Chinese population.

The host immune system plays a crucial role in the surveillance, recognition and elimination of tumor cells. Recent studies found that Human lymphocyte antigen class I () genes, Killer cell immunoglobulin-like receptor () genes and combinations play a role in the defense against tumor cells. To evaluated the associations between genes, genes and combinations and non-small cell lung cancer (NSCLC) in a Chinese Han population, a total of 229 patients with NSCLC (adenocarcinoma) and 217 healthy individuals were studied. Our results showed that the allele occurred at a significantly higher frequency in the NSCLCs compared with the controls (=0.034). The haplotype frequencies bearing , , and loci between the NSCLC and control groups were not different (>0.05). And there were no differences in the gene, genotype and haplotype frequencies between the NSCLC and control groups (>0.05). Also, there were no differences between the combinations in the genes and , ligands and genes and HLA-C1/C2 ligands between the NSCLC and control groups (>0.05). Our results indicate that the allele could be a risk factor for NSCLC (adenocarcinoma) in the Chinese Han population (OR=2.395; 95% CI: 1.359-4.221).