Wolf Kayla J, Kumar Sanjay
University of California, Berkeley - University of California, San Francisco Graduate Program in Bioengineering, Berkeley, California, 94720, USA.
Department of Bioengineering, University of California, Berkeley, Berkeley, California, 94720, USA.
ACS Biomater Sci Eng. 2019 Aug 12;5(8):3753-3765. doi: 10.1021/acsbiomaterials.8b01268. Epub 2019 Jan 27.
In the last few decades, hyaluronic acid (HA) has become increasingly employed as a biomaterial in both clinical and research applications. The abundance of HA in many tissues, together with its amenability to chemical modification, has made HA an attractive material platform for a wide range of applications including regenerative medicine, drug delivery, and scaffolds for cell culture. HA has traditionally been appreciated to modulate tissue mechanics and remodeling through its distinctive biophysical properties and ability to organize other matrix proteins. However, HA can influence cell behavior in much more direct and specific ways by engaging cellular HA receptors, which can trigger signals that influence cell survival, proliferation, adhesion, and migration. In turn, cells modify HA by regulating synthesis and degradation through a dedicated arsenal of enzymes. Optimal design of HA-based biomaterials demands full consideration of these diverse modes of regulation. This review summarizes how HA-based signaling regulates cell behavior and discusses how these signals can be leveraged to create cell-instructive biomaterials.
在过去几十年里，透明质酸（HA）在临床和研究应用中越来越多地被用作生物材料。HA在许多组织中含量丰富，加上其易于化学修饰，使其成为一个有吸引力的材料平台，可用于包括再生医学、药物递送和细胞培养支架在内的广泛应用。传统上，人们认为HA通过其独特的生物物理特性和组织其他基质蛋白的能力来调节组织力学和重塑。然而，HA可以通过与细胞HA受体结合，以更直接和特定的方式影响细胞行为，这些受体可以触发影响细胞存活、增殖、粘附和迁移的信号。反过来，细胞通过一系列专门的酶调节合成和降解来修饰HA。基于HA的生物材料的优化设计需要充分考虑这些不同的调节模式。本综述总结了基于HA的信号传导如何调节细胞行为，并讨论了如何利用这些信号来创建具有细胞指导作用的生物材料。
