通过 PdNP 生物纳米杂化催化剂在水相介质中催化的 C-H 活化实现色氨酸和蛋白质色氨酸残基的位点选择性修饰。
Site-selective modification of tryptophan and protein tryptophan residues through PdNP bionanohybrid-catalysed C-H activation in aqueous media.
机构信息
Department of Biocatalysis, Institute of Catalysis (ICP-CSIC), Marie Curie 2, Cantoblanco, Campus UAM, 28049 Madrid, Spain.
Instituto Aragonés de Ciencias de la Salud (IACS), Zaragoza, 50009, Spain and Institute of Biocomputation and Physics of Complex Systems (BIFI), Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Universidad de Zaragoza, Zaragoza, 50018, Spain.
出版信息
Chem Commun (Camb). 2019 Oct 24;55(86):12928-12931. doi: 10.1039/c9cc06971b.
Herein we report for the first time the site-selective C-H bond arylation of tryptophan and tryptophan residues in proteins in aqueous media at room temperature by using a PdNP bionanohybrid as a heterogeneous catalyst. The reaction proceeds using a stable aryldiazonium salt without a base.
在这里，我们首次报道了在水相介质中，在室温下使用 PdNP 仿生纳米杂化作为多相催化剂，对色氨酸和蛋白质中天冬氨酸残基的选择性 C-H 键芳基化反应。该反应在无需使用碱的情况下，使用稳定的芳基重氮盐进行。
Zotero 插件